N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluoro-benzamide | 1003050-32-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluoro-benzamide
• 英文别名: N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide；2,3,4,5,6-pentafluoro-N-(2-methylcyclohexyl)benzamide
• CAS: 1003050-32-5
• 化学式: C₁₄H₁₄F₅NO
• 分子量: 307.263
• InChiKey: FJHJJVNLPPPLHC-UHFFFAOYSA-N

物化性质

• LogP：
  4.027 (est)
• 物理描述：
  White solid; Cooling aroma
• 溶解度：
  Slightly soluble in water; Soluble in most organic solvents

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  五氟苯甲酰氯 、 2-甲基环己胺 以A white solid was obtained in a yield of 83%的产率得到N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluoro-benzamide
  参考文献：
  名称：

  Benzamide Compounds Useful as High Potency Sweet Taste Enhancers

  摘要：

  本发明涉及新型苯甲酰胺化合物，可用于提供甜味的理想特性以及用于食品、口香糖、药品、牙膏、酒精饮料、水饮料、零食、调味汁、糖果、烘焙食品、乳制品或谷物中。

  公开号：

  US20090047379A1

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10392371B2

  公开（公告）日：2019-08-27

  Provided herein are compounds which are useful as cooling sensation compounds.

  本文提供的化合物可用作冷感化合物。
• Methods and compositions for improved taste quality
  申请人：Almendra Pte. Ltd

  公开号：US10602758B2

  公开（公告）日：2020-03-31

  In one aspect, the disclosure relates to sweetener compositions, methods of making same, and products comprising same. In various aspects, the disclosed sweetener compositions comprise a sweetening agent and a taste modulator component. The taste modulator component improves key properties associated with many sweetening agents, including maximal sweetness response; mitigates flavor profile issues such as bitter and/or licorice-like off-tastes; improves sweetness onset rate and lingering sweet aftertaste properties; improves desensitization/adaptation profile issues; and improves body/mouthfeel characteristics. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  在一个方面，本公开涉及甜味剂组合物、甜味剂组合物的制造方法以及包含甜味剂组合物的产品。在各个方面，所公开的甜味剂组合物包括甜味剂和口味调节剂成分。味觉调节剂成分可改善与许多甜味剂相关的关键特性，包括最大甜味反应；减轻风味特征问题，如苦味和/或甘草样异味；改善甜味起始率和甜味回味特性；改善脱敏/适应特征问题；以及改善体感/口感特征。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• High intensity sweeteners
  申请人：Firmenich Incorporated

  公开号：US11357246B2

  公开（公告）日：2022-06-14

  Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.

  本文公开了具有结构式（I）的化合物或其盐类。这些化合物可用作甜味剂和/或甜味增强剂。还公开了包含本化合物的组合物以及增加可食用组合物甜味的方法。此外，还公开了制备这些化合物的方法。