forsythialanside C | 1616079-10-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: forsythialanside C
• CAS: 1616079-10-7
• 化学式: C₃₂H₄₄O₁₅
• 分子量: 668.692
• InChiKey: WCWONPIJTWXCFI-HOUMTNNSSA-N

物化性质

• 沸点：
  862.7±65.0 °C(predicted)
• 密度：
  1.50±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.13
• 重原子数：
  47.0
• 可旋转键数：
  12.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  226.45
• 氢给体数：
  8.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  forsythialanside C 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 二氢去氢二愈创木基醇
  参考文献：
  名称：

  Quinoid glycosides from Forsythia suspensa

  摘要：

  Phytochemical investigation on Forsythia suspensa (Thunb.) Vahl afforded 10 compounds, including quinoid glycosides, lignan glycosides, phenylethanoid glycoside and allylbenzene glycoside together with 13 known ones. Their structures were established based on extensive spectroscopic data analyses, including IR, UV, HRESIMS, 1D NMR and 2D NMR. Absolute configurations were determined by ECD calculation method and chemical degradation. In addition, all compounds were evaluated for their antiviral activity against influenza A (H1N1) virus and several were further evaluated against respiratory syncytial virus (RSV) in vitro. Among them, two previously known compounds showed significant activities against RSV with EC50 values of 3.43 and 6.72 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2014.04.010

文献信息

• Quinoid glycosides from Forsythia suspensa
  作者：Chang Li、Yi Dai、Shu-Xiang Zhang、Ying-Hui Duan、Ming-Li Liu、Liu-Yuan Chen、Xin-Sheng Yao

  DOI：10.1016/j.phytochem.2014.04.010

  日期：2014.8

  Phytochemical investigation on Forsythia suspensa (Thunb.) Vahl afforded 10 compounds, including quinoid glycosides, lignan glycosides, phenylethanoid glycoside and allylbenzene glycoside together with 13 known ones. Their structures were established based on extensive spectroscopic data analyses, including IR, UV, HRESIMS, 1D NMR and 2D NMR. Absolute configurations were determined by ECD calculation method and chemical degradation. In addition, all compounds were evaluated for their antiviral activity against influenza A (H1N1) virus and several were further evaluated against respiratory syncytial virus (RSV) in vitro. Among them, two previously known compounds showed significant activities against RSV with EC50 values of 3.43 and 6.72 mu M. (C) 2014 Elsevier Ltd. All rights reserved.