2-methyl-2-(4-methoxyphenyl)-1-propanamine hydrochloride | 51558-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-2-(4-methoxyphenyl)-1-propanamine hydrochloride
• 英文别名: 2-(4-methoxy-phenyl)-2-methyl-propylamine; hydrochloride；2-(4-Methoxyphenyl)-2-methylpropan-1-amine hydrochloride；2-(4-methoxyphenyl)-2-methylpropan-1-amine;hydrochloride
• CAS: 51558-26-0
• 化学式: C₁₁H₁₇NO*ClH
• mdl: MFCD00456906
• 分子量: 215.723
• InChiKey: DVMZBORVZRSFJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-2-(4-methoxyphenyl)-1-propanamine hydrochloride 在 sodium 作用下， 以 乙醇 、 水 为溶剂， 反应 22.0h， 生成 1-<2-(4-Methoxyphenyl)-2-methylpropyl>pyrimidin-2,4,6(1H,3H,5H)-trion
  参考文献：
  名称：

  模具合成6,7-二氢-2 H-嘧啶[ 6，1- a ]异chinolinolin -4（3 H）-和类似物Verbindungen和deren Wirkung alsBlutpättchenaggregateshemomer

  摘要：

  6,7-二氢-2 H-嘧啶基[6,1 - a ]异喹啉-4（3 H）-ones及其类似化合物的合成及其作为血小板抑制剂的活性

  DOI：

  10.1002/hlca.19860690722
• 作为产物：
  描述：

  2-(4-甲氧苯基)-2-甲基丙烷-1-胺 在 盐酸 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 以1.1 kg的产率得到2-methyl-2-(4-methoxyphenyl)-1-propanamine hydrochloride
  参考文献：
  名称：

  Effects of Various Bases on Acid-Catalyzed Amination of 2-Chloro-5-ethylpyrimidine: Synthesis of PPARpan Agonist GW693085

  摘要：

  A unique buffering effect of various bases, i-Pr2NEt and CaCO3 in particular, was observed for the acid-catalyzed chloro displacement of 2-chloro-5-ethylpyrimidine with a 2-methyl-2-phenylpropanamine. The use of the carefully chosen bases was essential for the progression of the chloro displacement as well as the stability of the product in the presence of HCl formed. Research work leading to an efficient synthesis of PPARpan agonist GW693085 is described, featuring highly selective sequential N- and O-alkylations.

  DOI：

  10.1021/jo100562s

文献信息

• KIENZLE F.; BOUNAMEAUX Y.; MINDER R. E.; MUGGLI R., HELV. CHIM. ACTA, 69,(1986) N 7, 1671-1680
  作者：KIENZLE F.、 BOUNAMEAUX Y.、 MINDER R. E.、 MUGGLI R.

  DOI：——

  日期：——
• CALCILYTIC COMPOUNDS
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP0901459A1

  公开（公告）日：1999-03-17
• [EN] CALCILYTIC COMPOUNDS<br/>[FR] COMPOSES CALCILYTIQUES
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：WO1997037967A1

  公开（公告）日：1997-10-16

  (EN) The present invention features calcilytic compounds. 'Calcilytic compounds' refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.(FR) La présente invention concerne des 'composés calcilytiques', c'est-à-dire des composés pouvant inhiber l'activité du récepteur du calcium. On décrit également l'utilisation de ces composés pour inhiber l'activité dudit récepteur et/ou obtenir un effet bénéfique chez un patient, ainsi que des techniques que l'on peut utiliser pour obtenir d'autres composés calcilytiques.
• Effects of Various Bases on Acid-Catalyzed Amination of 2-Chloro-5-ethylpyrimidine: Synthesis of PPARpan Agonist GW693085
  作者：Bobby N. Glover、Lynda A. Jones、Byron, S. Johnson、Alan Millar、Martin H. Osterhout、Shiping Xie

  DOI：10.1021/jo100562s

  日期：2010.6.4

  A unique buffering effect of various bases, i-Pr2NEt and CaCO3 in particular, was observed for the acid-catalyzed chloro displacement of 2-chloro-5-ethylpyrimidine with a 2-methyl-2-phenylpropanamine. The use of the carefully chosen bases was essential for the progression of the chloro displacement as well as the stability of the product in the presence of HCl formed. Research work leading to an efficient synthesis of PPARpan agonist GW693085 is described, featuring highly selective sequential N- and O-alkylations.
• Die Synthese von 6,7-Dihydro-2<i>H</i>-pyrimido[6, 1-<i>a</i>]isochinolin-4(3<i>H</i>)-onen und analogen Verbindungen und deren Wirkung als Blutpättchenaggregationshemmer
  作者：Frank Kienzle、Yves Bounameaux、Rudolf E. Minder、Reto Muggli

  DOI：10.1002/hlca.19860690722

  日期：1986.10.29

  Synthesis of 6,7-Dihydro-2H-pyrimido[6,1-a]isoquinolin-4(3H)-ones and Analogous Compounds and their Activity as Blood-Platelet Inhibitors

  6,7-二氢-2 H-嘧啶基[6,1 - a ]异喹啉-4（3 H）-ones及其类似化合物的合成及其作为血小板抑制剂的活性