o-(Aminocarbamoyl)benzamide | 164415-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-(Aminocarbamoyl)benzamide
• 英文别名: phthalamic acid hydrazide；Phthalamidsaeure-hydrazid；Phthalamohydrazide；2-(hydrazinecarbonyl)benzamide
• CAS: 164415-13-8
• 化学式: C₈H₉N₃O₂
• 分子量: 179.178
• InChiKey: AYAAHABXYMCPRV-UHFFFAOYSA-N

物化性质

• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  o-(Aminocarbamoyl)benzamide 在 Na₂CO₃ buffer 作用下， 以 水 、 乙腈 为溶剂， 生成 邻苯二甲酰肼
  参考文献：
  名称：

  Kinetic Evidence for the Occurrence of a Stepwise Mechanism in the Hydrazinolysis of Phthalimide

  摘要：

  The apparent second-order rate constants, k(napp), for the reaction of hydrazine with phthalimide at a constant pH follow the empirical relationship k(napp) = A(1)[Am](T)/(1 + A(2)[Am](T)), where [Am](T) represents the total hydrazine buffer concentration. The nonlinear variation of k(napp) against [Am](T) is attributed to the change in the rate-determining step with change in [Am](T) at a constant pH, and this provides evidence for the existence of an intermediate on the reaction path. The cyclization of o-(aminocarbamoyl)benzamide to 2,3-dihydrophthalazine-1,4-dione involves N-aminophthalimide as the intermediate.

  DOI：

  10.1021/jo00119a035
• 作为产物：
  描述：

  邻苯二甲酸亚胺 在 肼 作用下， 以 水 、 乙腈 为溶剂， 生成 o-(Aminocarbamoyl)benzamide
  参考文献：
  名称：

  Kinetic Evidence for the Occurrence of a Stepwise Mechanism in the Hydrazinolysis of Phthalimide

  摘要：

  The apparent second-order rate constants, k(napp), for the reaction of hydrazine with phthalimide at a constant pH follow the empirical relationship k(napp) = A(1)[Am](T)/(1 + A(2)[Am](T)), where [Am](T) represents the total hydrazine buffer concentration. The nonlinear variation of k(napp) against [Am](T) is attributed to the change in the rate-determining step with change in [Am](T) at a constant pH, and this provides evidence for the existence of an intermediate on the reaction path. The cyclization of o-(aminocarbamoyl)benzamide to 2,3-dihydrophthalazine-1,4-dione involves N-aminophthalimide as the intermediate.

  DOI：

  10.1021/jo00119a035

文献信息

• Electrophotographic organophotoreceptors with novel charge transport compounds
  申请人：Samsung Information Systems America

  公开号：US20030113132A1

  公开（公告）日：2003-06-19

  A novel charge transport compound, a novel process using that novel compound and an organophotoreceptor includes: (a) a novel charge transport compound having the formula 1 where R 1 and R 2 are selected so that R 1 and R 2 form, with the included nitrogen atom, a group selected from the group consisting of heterocyclic rings, aromatic rings, and dinaphthylamine; or R 1 comprises an aryl group and R 2 comprises a group selected from the group consisting of sulfolanyl, 4-(9H-fluoren-9-ylidene)benzyl, pyrrolyl, pyrazolyl, benzotriazolyl, stilbenyl, tetrazolyl; or R 1 comprises hydrogen, alkyl group, aryl group and R 2 comprises sulfonylphenyl. R 3 is hydrogen, alkyl group, aryl group, heterocyclic group or a hydrocarbon group; and Q is a 3-carbazole group; (b) a charge generating compound; and (c) an electrically conductive substrate.

  一种新颖的电荷传输化合物，一种使用该新颖化合物的新颖工艺以及一种包括有机光感受器的器件包括：（a）具有下列结构式1的新颖电荷传输化合物，其中R1和R2被选为使得R1和R2与所含的氮原子形成从异环丙烷环、芳香环和二萘胺中选择的群组成的群组；或者R1包括芳基基团，R2包括从亚砜亚基、4-(9H-芴-9-基)苯基、吡咯基、吡唑基、苯并三氮唑基、亚苯基、四唑基中选择的群组；或者R1包括氢、烷基基团、芳基基团，R2包括磺酰基苯基。R3是氢、烷基基团、芳基基团、异环基团或烃基团；Q是3-咔唑基团；（b）电荷生成化合物；和（c）电导基板。
• BETA 3 ADRENERGIC AGONISTS
  申请人：Bastian Anne Jolie

  公开号：US20060142327A1

  公开（公告）日：2006-06-29

  The present invention relates to a β3 adrenergic receptor agonist of formula (1) or a pharmaceutical salt thereof; useful for treating Type II diabetes and/or obesity.

  本发明涉及一种式（1）的β3肾上腺素能受体激动剂或其药物盐；用于治疗II型糖尿病和/或肥胖症。
• 3-substituted oxindole beta3 agonists
  申请人：Bastian Anne Jolie

  公开号：US20050020617A1

  公开（公告）日：2005-01-27

  The present invention relates to a β3 adrenegc receptor agonist of Formula (I) or a pharmaceutical salt thereof; useful for treating Type II diabetess and/or obesity.

  本发明涉及一种式（I）的β3肾上腺素受体激动剂或其药物盐；用于治疗2型糖尿病和/或肥胖症。
• Beta 3 adrenergic agonists
  申请人：Bastian Anne Jolie

  公开号：US20050020618A1

  公开（公告）日：2005-01-27

  The present invention relates to a β3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof; useful for treating Type II diabetes and/or obesity.

  本发明涉及一种公式（I）的β3肾上腺素能受体激动剂或其药用盐；适用于治疗II型糖尿病和/或肥胖症。
• Electrophotographic organophotoreceptors with charge transport compounds
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP1283448A2

  公开（公告）日：2003-02-12

  A novel charge transport compound, a novel process using that novel compound and an organophotoreceptor includes (a) a novel charge transport compound having the formula where R1 and R2 are selected so that R1 and R2 form, with the included nitrogen atom, a group selected from the group consisting of heterocyclic rings, aromatic rings, and dinaphthylamine; or R1 comprises an C5-C40 aryl group and R2 comprises a group selected from the group consisting of sulfolanyl, 4-(9H-fluoren-9-ylidene)benzyl, pyrrolyl, pyrazolyl, benzotriazolyl, stilbenyl, tetrazolyl; or R1 comprises hydrogen, C1-C30 alkyl group, C5-C40 aryl group and R2 comprises sulfonylphenyl, R3 is hydrogen, C1-C30 alkyl group, C5-C40 aryl group, heterocyclic group or a hydrocarbon group; and Q is a 3-carbazole group; (b) a charge generating compound; and (c) an electrically conductive substrate.

  一种新型电荷传输化合物、一种使用该新型化合物的新型工艺和一种有机光感受器包括 (a) 具有以下式子的新型电荷传输化合物 其中 R1 和 R2 的选择是使 R1 和 R2 与所包含的氮原子形成选自由杂环、芳香环和二萘胺组成的基团；或 R1 包括 C5-C40 芳基，R2 包括选自由苯磺酰基、4-(9H-芴-9-亚基)苄基、吡咯基、吡唑基、苯并三唑基、二苯乙烯基、四唑基组成的基团；或 R1 包括氢、C1-C30 烷基、C5-C40 芳基，R2 包括磺酰基苯基，R3 为氢、C1-C30 烷基、C5-C40 芳基、杂环基或烃基；以及 Q 为 3-咔唑基； (b) 电荷生成化合物；以及 (c) 导电基底。