(E)-3-methyl-2-(2-phenylethenyl)furan | 908137-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-methyl-2-(2-phenylethenyl)furan
• 英文别名: 3-methyl-2-(2-phenylethenyl)furan；3-methyl-2-[(E)-2-phenylethenyl]furan
• CAS: 908137-94-0
• 化学式: C₁₃H₁₂O
• 分子量: 184.238
• InChiKey: GPKFLFQJFQFCDA-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-3-methyl-2-(2-phenylethenyl)furan 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 生成
  参考文献：
  名称：

  杂芳环中带有中心双键的新型共轭ω，ω'-二芳基/杂芳基己三烯系统的合成：2,3-二乙烯基呋喃衍生物的光化学转化

  摘要：

  合成了新的β，β′-芳基/杂芳基2，3-二乙烯基呋喃衍生物（9a – d），其中己三烯系统是杂芳环的一部分，并对其光化学性质进行了研究。观察到的主要过程是异构化为反式，反式异构体9a – d，然后呋喃环发生光化学重排，从而得到光转座产物（I – IV）。芪（20，21）和菲（22，25，和26也观察到了由竞争性分子间环加成反应形成的副产物）。

  DOI：

  10.1016/j.tet.2006.05.034
• 作为产物：
  描述：

  (E)-2,3-dihydro-2-methoxy-5-methyl-2-(2-phenylethenyl)furan 在 tetrafluoroboric acid 、 silica gel 作用下， 以 乙酸乙酯 为溶剂， 以55%的产率得到(E)-3-methyl-2-(2-phenylethenyl)furan
  参考文献：
  名称：

  Fischer卡宾配合物与α，β-不饱和酮和醛的[4 + 1] / [2 + 1]环加成反应。

  摘要：

  DOI：

  10.1002/anie.200605167

文献信息

• COMBINATION PRODUCT FOR THE INDUCTION AND/OR MAINTENANCE OF GENERAL ANESTHESIA
  申请人：BLUMENTECH, S.L.

  公开号：US20210186927A1

  公开（公告）日：2021-06-24

  The state of general anesthesia (GA) is essential to many surgical and medical procedures. This state is characterized by loss of consciousness, deep analgesia and suppression of movements. GA is rarely achieved with a single drug, usually requiring the combination of various pharmacological agents. Each drug can interact with one or more molecular targets affecting neuronal excitability and synaptic transmission in multiple regions of the CNS. Agonists of the μ-opioid receptor are commonly used in GA to cause analgesia, but not to induce or maintain loss of consciousness or movement suppression. Additionally, agonists of the μ-opioid receptor can cause serious unwanted side effects, e.g. respiratory depression. The present invention provides alternative combination products based on K-opioid receptor agonists. These combination products unexpectedly induced loss of consciousness, and were able to achieve and maintain GA. Furthermore, the combination products suppressed pain perception without the need of a μ-opioid receptor agonist. The combination of Salvinorin A, a selective κ-opioid receptor agonist, with Diazepam or Medetomidine surprisingly led to rapid consciousness, deep analgesia and movement suppression. This combination was found to effectively induce and maintain a state of general anesthesia.
• [4+1]/[2+1] Cycloaddition Reactions of Fischer Carbene Complexes with α,β-Unsaturated Ketones and Aldehydes
  作者：José Barluenga、Hugo Fanlo、Salomé López、Josefa Flórez

  DOI：10.1002/anie.200605167

  日期：2007.5.25
• Synthesis of the novel conjugated ω,ω′-diaryl/heteroaryl hexatriene system with the central double bond in a heteroaromatic ring: photochemical transformations of 2,3-divinylfuran derivatives
  作者：Irena Škorić、Ivana Flegar、Željko Marinić、Marija Šindler-Kulyk

  DOI：10.1016/j.tet.2006.05.034

  日期：2006.7

  New β,β′-aryl/heteroaryl 2,3-divinylfuran derivatives (9a–d) in which a hexatriene system is a part of heteroaromatic ring have been synthesized and their photochemical properties were investigated. The primary process observed was the isomerization to trans,trans-isomers 9a–d followed by photochemical rearrangement of the furan ring giving the phototransposition products (I–IV). Stilbenes (20, 21)

  合成了新的β，β′-芳基/杂芳基2，3-二乙烯基呋喃衍生物（9a – d），其中己三烯系统是杂芳环的一部分，并对其光化学性质进行了研究。观察到的主要过程是异构化为反式，反式异构体9a – d，然后呋喃环发生光化学重排，从而得到光转座产物（I – IV）。芪（20，21）和菲（22，25，和26也观察到了由竞争性分子间环加成反应形成的副产物）。