5'-Bromo-6-methoxy-2,3'-bipyridine | 383426-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5'-Bromo-6-methoxy-2,3'-bipyridine
• 英文别名: 2-(5-bromopyridin-3-yl)-6-methoxypyridine
• CAS: 383426-20-8
• 化学式: C₁₁H₉BrN₂O
• 分子量: 265.109
• InChiKey: XTSWKEBFDMQAHW-UHFFFAOYSA-N

物化性质

• 沸点：
  331.1±37.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5'-Bromo-6-methoxy-2,3'-bipyridine 在 sodium tetrahydroborate 、 正丁基锂 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 (6-methoxy-[2,3']bipyridinyl-5'-yl)-methanol
  参考文献：
  名称：

  Construction of functionalized/substituted bipyridines by means of Negishi cross-coupling reactions. Formal synthesis of (±)-cytisine

  摘要：

  The use of Negishi cross-coupling reaction allows the construction of various substituted and functionalized bipyridines. The efficiency of the method permits to obtain in high yield a direct precursor of racemic cytisine. (C), 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01664-1
• 作为产物：
  描述：

  3,5-二溴吡啶 、 2-溴-6-甲氧基吡啶 以79%的产率得到5'-Bromo-6-methoxy-2,3'-bipyridine
  参考文献：
  名称：

  Construction of functionalized/substituted bipyridines by means of Negishi cross-coupling reactions. Formal synthesis of (±)-cytisine

  摘要：

  The use of Negishi cross-coupling reaction allows the construction of various substituted and functionalized bipyridines. The efficiency of the method permits to obtain in high yield a direct precursor of racemic cytisine. (C), 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01664-1

文献信息

• Construction of functionalized/substituted bipyridines by means of Negishi cross-coupling reactions. Formal synthesis of (±)-cytisine
  作者：Prosper Nshimyumukiza、Dominique Cahard、Jacques Rouden、Marie-Claire Lasne、Jean-Christophe Plaquevent

  DOI：10.1016/s0040-4039(01)01664-1

  日期：2001.10

  The use of Negishi cross-coupling reaction allows the construction of various substituted and functionalized bipyridines. The efficiency of the method permits to obtain in high yield a direct precursor of racemic cytisine. (C), 2001 Elsevier Science Ltd. All rights reserved.