benzyl phosphinate | 18108-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl phosphinate
• 英文别名: Phosphorosooxymethylbenzene
• CAS: 18108-16-2
• 化学式: C₇H₇O₂P
• 分子量: 154.105
• InChiKey: JRPGPMLROWPYLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzyl phosphinate 、 2-(2-benzoyl-1-phenyl-2-propen-1-yl)cyclohexanone 以10%的产率得到
  参考文献：
  名称：

  VYSOTSKIJ, V. I.;PRIXODKO, YU. V.;PAVEL, G. V.;TILICHENKO, M. N., ZH. OBSHCH. XIMII, 1985, 55, N 11, 2475-2481

  摘要：

  DOI：

文献信息

• [EN] NOVEL SYNTHETIC DINUCLEOSIDE POLYPHOSPHATE ANALOGS AND THEIR USE AS NEW THERAPEUTIC AND/OR DIAGNOSTIC MODALITIES<br/>[FR] NOUVEAUX ANALOGUES SYNTHÉTIQUES DE DINUCLÉOSIDE POLYPHOSPHATE ET LEUR UTILISATION COMME NOUVELLES MODALITÉS THÉRAPEUTIQUES ET/OU DIAGNOSTIQUES
  申请人：ZATA PHARMACEUTICALS INC

  公开号：WO2010056795A1

  公开（公告）日：2010-05-20

  The invention provides novel synthetic dinucleoside polyphosphate analogs and their use as therapeutic compounds and/or diagnostic tools for the treatment and diagnosis of various human diseases and metabolic disorders.

  这项发明提供了新型合成二核苷酸聚磷酸盐类似物及其作为治疗化合物和/或诊断工具用于治疗和诊断各种人类疾病和代谢紊乱。
• PROCESSES FOR PREPARING (E)-STYRYLBENZYLSULFONE COMPOUNDS AND USES THEREOF FOR TREATING PROLIFERATIVE DISORDERS
  申请人：SIRIGIREDDY REDDY

  公开号：US20100152491A1

  公开（公告）日：2010-06-17

  Processes for preparing (E)-2,4,6-(Trimethoxystyryl)-3-O-Phosphate Disodium-4-Methoxybenzyl Sulfones and uses thereof as antiproliferative agents, including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

  制备(E)-2,4,6-(三甲氧基苯乙烯基)-3-O-磷酸二钠-4-甲氧基苯甲基磺酮的方法及其作为抗增殖剂的用途，包括作为抗癌剂，以及作为放射保护和化学保护剂的用途。
• PROCESS FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE, AND CATALYST COMPOSITION FOR THE PRODUCTION OF POLYURETHANE RESIN USING IT
  申请人：Tokumoto Katsumi

  公开号：US20110077376A1

  公开（公告）日：2011-03-31

  To provide a process for producing a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine simply and in a small number of steps without requiring multi-stage reaction steps; a novel catalyst composition whereby a polyurethane product can be obtained with good productivity and good moldability without bringing about odor problems or environmental problems; and a process for producing a polyurethane resin using the catalyst composition. For example, a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine is produced by subjecting a mono-substituted dihydroxyalkylpiperazine and/or a di-substituted hydroxyalkylpiperazine to an intramolecular dehydration condensation reaction in the presence of an acid catalyst. Further, for example, a polyurethane resin is produced by using a catalyst composition which comprises a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine (A), and an amine compound (B) having, in its molecule, one or more substituents selected from the group consisting of a hydroxy group, a primary amino group and a secondary amino group, or a tertiary amine compound (C) having a value of [blowing reaction rate constant/gelling reaction rate constant] of at least 0.5.

  提供一种简单且步骤较少的工艺，用于生产羟基烷基三乙烯二胺或羟基三乙烯二胺，而无需进行多级反应步骤；一种新颖的催化剂组合物，可以在不产生异味或环境问题的情况下获得具有良好生产率和良好成型性的聚氨酯产品；以及使用催化剂组合物生产聚氨酯树脂的工艺。例如，通过在酸催化剂存在下，使单取代二羟基烷基哌嗪和/或双取代羟基烷基哌嗪经历分子内脱水缩合反应，可以生产羟基烷基三乙烯二胺或羟基三乙烯二胺。此外，例如，使用催化剂组合物生产聚氨酯树脂，该组合物包括羟基烷基三乙烯二胺或羟基三乙烯二胺（A），以及在其分子中具有一个或多个取代基的胺化合物（B），所述取代基选自羟基、一级胺基和二级胺基的群，或者具有至少0.5的[发泡反应速率常数/凝胶反应速率常数]值的三级胺化合物（C）。
• HEPTOSE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
  申请人：Gerusz Vincent

  公开号：US20140024576A1

  公开（公告）日：2014-01-23

  Compounds having the general formula (I) pharmaceutical compositions containing them for use in inhibiting bacterial heptose biosynthesis and thereby lowering or suppressing bacterial virulence.

  具有通式(I)的化合物，以及含有它们的制药组合物，可用于抑制细菌七糖生物合成，从而降低或抑制细菌的毒力。
• Beta-lactam antibiotics
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0048953A2

  公开（公告）日：1982-04-07

  β-Lactams having a sulfonic acid substituent in the 1-position and one or two substituents as specified in the 4-position and an amine function in the 3-position and their use as antibiotics.

  1 位有一个磺酸取代基，4 位有一个或两个指定取代基，3 位有一个胺功能的 β-内酰胺及其作为抗生素的用途。