trans-cinnamylhydrazine; hydrochloride | 69717-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-cinnamylhydrazine; hydrochloride
• 英文别名: trans-Cinnamylhydrazin; Hydrochlorid；[(E)-3-phenylprop-2-enyl]hydrazine;hydrochloride
• CAS: 69717-89-1
• 化学式: C₉H₁₂N₂*ClH
• 分子量: 184.669
• InChiKey: NFERCJTWCQRBMG-KQGICBIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.58
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-cinnamylhydrazine; hydrochloride 、 3-溴丙炔 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以28%的产率得到N-((E)-3-Phenyl-allyl)-N-prop-2-ynyl-hydrazine
  参考文献：
  名称：

  Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

  摘要：

  A series of N-1- and N-2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N-1- and N-2-propargylphenelzines. (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00549-2
• 作为产物：
  描述：

  di-tert-butyl 1-cinnamylhydrazine-1,2-dicarboxylate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以76%的产率得到trans-cinnamylhydrazine; hydrochloride
  参考文献：
  名称：

  Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

  摘要：

  A series of N-1- and N-2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N-1- and N-2-propargylphenelzines. (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00549-2

文献信息

• WOLFF, H. P.;KUEHNLE, H. F., J. MED. CHEM., 1985, 28, N 10, 1436-1440
  作者：WOLFF, H. P.、KUEHNLE, H. F.

  DOI：——

  日期：——
• US4136196A
  申请人：——

  公开号：US4136196A

  公开（公告）日：1979-01-23
• Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
  作者：Lei Ling、Liana J. Urichuk、B.Duff Sloley、Ronald T. Coutts、Glen B. Baker、Jacqueline J. Shan、Peter K.T. Pang

  DOI：10.1016/s0960-894x(01)00549-2

  日期：2001.10

  A series of N-1- and N-2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N-1- and N-2-propargylphenelzines. (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties. (C) 2001 Elsevier Science Ltd. All rights reserved.