2-methyl-octylamine | 1081974-54-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-octylamine
• 英文别名: (β-Methyl-n-octyl)-amin；α-Amino-β-methyl-octan；1-Amino-2-methyl-octan；2-Methyloctan-1-amine
• CAS: 1081974-54-0
• 化学式: C₉H₂₁N
• 分子量: 143.272
• InChiKey: QSVVOTNSTSRPQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  190.4±8.0 °C(Predicted)
• 密度：
  0.790±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-octylamine 在 4-二甲氨基吡啶 、 lithium hydroxide 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 54.0h， 生成 3-Methoxy-4-[1-methyl-5-(2-methyl-octylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid
  参考文献：
  名称：

  Substituted 3-(phenylmethyl)-1H-indole-5-carboxamides and 1-(phenylmethyl)indole-6-carboxamides as potent, selective, orally active antagonists of the peptidoleukotrienes

  摘要：

  Substituted indole-5-carboxamides and indole-6-carboxamides have been found to be potent and selective antagonists of the peptidoleukotrienes. Initial derivatives of these series (4-[[5-[(cyclopentylmethyl)carbamoyl]-1-methylindol-3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl] benzamide (5a) and 4-[[6-[(cyclopentylmethyl)carbamoyl]-3-methylindol-1-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide (6a), respectively), when compared to the corresponding indole amides (e.g. 28 and 29), were found to be approximately 10-fold less potent in vitro and substantially less active when administered orally to guinea pigs. Efforts to improve the potency of the title series by variation of the amide, indole, or sulfonamide substituents led to compounds of comparable in vitro potency to ICI 204,219, but of somewhat lower oral activity. A trend which suggested that more lipophilic transposed amides were needed to increase oral activity was exploited with some success and has led to the discovery of 5q (4-[[5-[(2-ethylbutyl)-carbamoyl]-1-ethylindol-3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide), a trans-posed amide with subnanomolar affinity for the leukotriene receptor and an oral ED50 of 5 mg/kg in a model of asthma in guinea pigs. In this model, ICI 204,219 was active at 0.4 mg/kg. The absolute bioavailability of 5q has been found to be 28% in the rat, as compared to 68% for ICI 204,219, with significant levels of 5q observed in the blood of rats up to 24 h postdose.

  DOI：

  10.1021/jm00055a011
• 作为产物：
  描述：

  2-氯辛烷 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-methyl-octylamine
  参考文献：
  名称：

  Kjaer,A. et al., Acta Chemica Scandinavica (1947), 1963, vol. 17, p. 2143 - 2154

  摘要：

  DOI：

文献信息

• [EN] ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANALOGUES D'ALKYLE PYRROLOPYRIMIDINE ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：UNIV NORTH CAROLINA CHAPEL HILL

  公开号：WO2018094227A1

  公开（公告）日：2018-05-24

  The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a Mer tyrosine kinase and/or a Tyro3 tyrosine kinase and methods of treating a bacterial infection, a viral infection, and/or a disorder of uncontrolled cellular proliferation such as, for example, a cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制Mer酪氨酸激酶和/或Tyro3酪氨酸激酶的苯并环戊二烯化合物，以及使用这些化合物治疗细菌感染、病毒感染和/或细胞不受控制增殖的疾病，例如癌症的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不意在限制本发明。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3825320A1

  公开（公告）日：2021-05-26

  Provided are an organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound:          Formula 1     M(L1)n1(L2)n2 wherein, in Formula 1, M, L1, L2, n1 and n2 may each be understood by referring to the descriptions thereof provided herein.

  本文提供了一种由式 1 表示的有机金属化合物、一种包括该有机金属化合物的有机发光器件以及一种包括该有机金属化合物的诊断组合物： 式 1 M(L1)n1(L2)n2 其中，式 1 中的 M、L1、L2、n1 和 n2 各可参阅本文对它们的描述来理解。
• Method for making an organoaminosilane; a method for making a silylamine from the organoaminosilane
  申请人：Dow Silicones Corporation

  公开号：US10875877B2

  公开（公告）日：2020-12-29

  A method of making an organoaminosilane compound, comprising i) combining A) a compound comprising a primary or secondary amine, B) monosilane (SiH4), and C) a catalyst, where the catalyst comprises magnesium or boron, where A), B) and C) are combined under sufficient conditions to form the organoaminosilane compound and hydrogen. A method of making a silylamine, the method comprising: i) forming an organoaminosilane compound by i) combining A) a compound comprising a primary or secondary amine, B) monosilane (SiH4), and C) a catalyst, where the catalyst comprises magnesium or boron, and ii) combining ammonia and the organoaminosilane compound produced in i) under sufficient conditions to form a silylamine product and a byproduct, where the byproduct is a primary or secondary amine.

  一种制造有机氨基硅烷化合物的方法，包括 i) 将 A) 由伯胺或仲胺组成的化合物、B) 单硅烷（SiH4）和 C) 催化剂结合，其中催化剂包括镁或硼，A)、B)和 C) 在足够的条件下结合以形成有机氨基硅烷化合物和氢。一种制造硅胺的方法，该方法包括：i)通过以下方法形成有机氨基硅烷化合物：i)将A)包含伯胺或仲胺的化合物、B)单硅烷(SiH4)和C)催化剂结合，其中催化剂包含镁或硼；和ii)在充分条件下将氨和i)中产生的有机氨基硅烷化合物结合，形成硅胺产物和副产物，其中副产物是伯胺或仲胺。
• High purity trisilylamine, methods of making, and use
  申请人：Jiangsu Nata Opto-Electronic Materials Co. Ltd.

  公开号：US11111256B2

  公开（公告）日：2021-09-07

  A composition, comprising: trisilylamine and less than 5 ppmw of halogen. A method of making a silylamine comprising combining ammonia and a compound comprising aminosilane functionality, where the compound comprising aminosilane functionality is according to formula (I) R1 N(R2)a(SiH3)2−a (I), where R1 is an organic polymer, a C-1-20 hydrocarbyl group or —SiR331, where R3 is C1-6 hydrocarbyl, R2 is a C-1-20 hydrocarbyl group, H, or —SiR331, where R3 is as defined above, subscript a is 0 or 1, provided that R1 and R2 may be the same or different except if R1 is phenyl, R2 is not phenyl, under sufficient conditions to cause a reaction to form a silylamine and a byproduct.

  一种组合物，包括：三硅烷基胺和小于 5 ppmw 的卤素。一种制造硅胺的方法，包括将氨与包含氨基硅烷官能团的化合物结合，其中包含氨基硅烷官能团的化合物根据式 (I) R1 N(R2)a(SiH3)2-a (I)，其中 R1 是有机聚合物、C-1-20 烃基或 -SiR331、其中 R3 为 C1-6 烃基，R2 为 C-1-20 烃基、H 或-SiR331，其中 R3 如上定义，下标 a 为 0 或 1，条件是 R1 和 R2 可以相同或不同，除非 R1 为苯基，R2 不是苯基，在足够的条件下引起反应生成硅胺和副产物。
• [EN] ANTI-WARPING HIGH-TEMPERATURE-RESISTANT REINFORCED POLYAMIDE COMPOSITION AND PREPARATION METHOD THEREFOR<br/>[FR] COMPOSITION DE POLYAMIDE RENFORCÉ, ANTI-GAUCHISSEMENT, RÉSISTANT À UNE TEMPÉRATURE ÉLEVÉE ET SON PROCÉDÉ DE PRÉPARATION<br/>[ZH] 抗翘曲耐高温增强聚酰胺组合物及其制备方法
  申请人：JIANGSU KINGFA SCI & TECH ADV MAT CO LTD

  公开号：WO2020038152A1

  公开（公告）日：2020-02-27

  一种抗翘曲耐高温增强聚酰胺组合物，包括以下重量百分含量组分：至少一种半结晶聚酰胺13.58‑82.98％；至少一种非结晶半芳香族聚酰胺2‑20％；金属盐化合物0.01‑5％；填料15‑60％；聚酰胺改性剂0.01‑12％。聚酰胺组合物在机械性能和表面外观上超越了现有的材料含金属盐、高支化化合物的聚酰胺组合物，具有多种改进的物理性能和成型性，包括模具零件表面外观的改善。