2-benzylidene-7-bromo-thiazolo[2',3':2,3]imidazo[4,5-b]pyridin-3-one | 107400-24-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-benzylidene-7-bromo-thiazolo[2',3':2,3]imidazo[4,5-b]pyridin-3-one
• 英文别名: 4-Benzylidene-10-bromo-5-thia-2,7,12-triazatricyclo[6.4.0.02,6]dodeca-1(8),6,9,11-tetraen-3-one
• CAS: 107400-24-8
• 化学式: C₁₅H₈BrN₃OS
• mdl: MFCD01076775
• 分子量: 358.218
• InChiKey: CVQLHIRUHLDQMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-溴-1,3-二氢-2H-咪唑并[4,5-b]吡啶-2-硫酮 在 sodium hydroxide 、 sodium acetate 、 乙酸酐 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2-benzylidene-7-bromo-thiazolo[2',3':2,3]imidazo[4,5-b]pyridin-3-one
  参考文献：
  名称：

  Synthesis and Antiproliferative Activity in vitro of New Tricyclic 2-Thioxo-1 H ,3 H -imidazo[4,5-b]pyridine Derivatives

  摘要：

  A series of 2-arylidenethiazolo[2',3':2,3]imidazo[4,5-b]pyridine-2-yl-3-ones were prepared by a reaction of 6-bromo- (4) or 3H-imidazo[4,5-b]pyridin-2-ylthioglycolic acid (3) with appropriate aromatic aldehydes. All new compounds were examined for their antiproliferative activity in vitro against cells of human cancer cell lines, using SRB technique. Preliminary screening data indicated that three of the tested compounds revealed cytotoxic activity.

  DOI：

  10.1080/10426500600892594

文献信息

• Prasad, A. R.; Rao, A. Narasimha; Ramalingam, T., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 776 - 778
  作者：Prasad, A. R.、Rao, A. Narasimha、Ramalingam, T.、Sattur, P. B.

  DOI：——

  日期：——
• Synthesis and Antiproliferative Activity in vitro of New Tricyclic 2-Thioxo-1<b> <i>H</i> </b>,3<b> <i>H</i> </b>-imidazo[4,5-<i>b</i>]pyridine Derivatives
  作者：Hanna Liszkiewicz、Maria W. Kowalska、Joanna Wietrzyk

  DOI：10.1080/10426500600892594

  日期：2007.1.1

  A series of 2-arylidenethiazolo[2',3':2,3]imidazo[4,5-b]pyridine-2-yl-3-ones were prepared by a reaction of 6-bromo- (4) or 3H-imidazo[4,5-b]pyridin-2-ylthioglycolic acid (3) with appropriate aromatic aldehydes. All new compounds were examined for their antiproliferative activity in vitro against cells of human cancer cell lines, using SRB technique. Preliminary screening data indicated that three of the tested compounds revealed cytotoxic activity.