dityrosol carbonate | 1449075-91-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: dityrosol carbonate
• 英文别名: bis(4-hydroxyphenylethyl) carbonate；Bis[2-(4-hydroxyphenyl)ethyl] carbonate；bis[2-(4-hydroxyphenyl)ethyl] carbonate
• CAS: 1449075-91-5
• 化学式: C₁₇H₁₈O₅
• 分子量: 302.327
• InChiKey: OONXJYGBRQYENG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对羟基苯乙醇 在 immobilized lipase from Candida antarctica B 作用下， 以 2-甲基-2-丁醇 为溶剂， 反应 2.17h， 生成 dityrosol carbonate
  参考文献：
  名称：

  Lipase-mediated flow synthesis of nature-inspired phenolic carbonates

  摘要：

  研究人员开发了一种简便易行的脂肪酶催化流程化学选择性合成酪醇和羟基酪醇甲基碳酸盐的方法。然后，制备出了高附加值的对称酪醇和羟基酪醇碳酸盐。

  DOI：

  10.1039/d3ra04735k

文献信息

• POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES
  申请人：Rutgers, The State University of New Jersey

  公开号：US20130203713A1

  公开（公告）日：2013-08-08

  The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

  本发明提供了新型酚类化合物，包括从酪醇和类似物中衍生的化合物，用作生物相容性聚合物的单体，以及从这些单体酚化合物制备的生物相容性聚合物，包括新型可降解和/或可吸收的聚合物。这些生物相容性聚合物或具有增强生物吸收性和加工性能的聚合物组合物在各种医疗应用中非常有用，例如在医疗器械和控释治疗配方中。该发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。
• Polymeric biomaterials derived from phenolic monomers and their medical uses
  申请人：Rutgers, The State University of New Jersey

  公开号：US10774030B2

  公开（公告）日：2020-09-15

  Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

  本发明公开了由酪醇或酪醇类似物和羟基苯甲酸衍生的新型二苯酚化合物，它们可用作制备生物相容性聚合物的单体。此外，还公开了由这些单体二苯酚化合物制备的生物相容性聚合物，包括新型生物可降解和/或生物可吸收的式聚合物。这些生物相容性聚合物或聚合物组合物具有增强的生物可吸收性和可加工性，可用于各种医疗应用，如医疗器械和控释治疗组合物。本发明还提供了制备这些单体二酚化合物和生物相容性聚合物的方法。
• US9416090B2
  申请人：——

  公开号：US9416090B2

  公开（公告）日：2016-08-16
• [EN] POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES<br/>[FR] BIOMATÉRIAUX POLYMÈRES DÉRIVÉS DE MONOMÈRES PHÉNOLIQUES ET LEURS UTILISATIONS MÉDICALES
  申请人：UNIV RUTGERS

  公开号：WO2017111994A1

  公开（公告）日：2017-06-29

  Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
• Lipase-mediated flow synthesis of nature-inspired phenolic carbonates
  作者：Sara Vicinanza、Francesca Annunziata、Desirèe Pecora、Andrea Pinto、Lucia Tamborini

  DOI：10.1039/d3ra04735k

  日期：——

  A facile and convenient lipase-catalyzed flow approach for the chemoselective synthesis of tyrosol and hydroxytyrosol methyl carbonates has been developed. Then, value-added symmetrical tyrosol and hydroxytyrosol carbonates were prepared.

  研究人员开发了一种简便易行的脂肪酶催化流程化学选择性合成酪醇和羟基酪醇甲基碳酸盐的方法。然后，制备出了高附加值的对称酪醇和羟基酪醇碳酸盐。