{3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine | 941320-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine
• 英文别名: 3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine；3-(3,4-dichlorophenoxy)-N,N-dimethyl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]propan-1-amine
• CAS: 941320-46-3
• 化学式: C₂₅H₃₄Cl₂N₂O₂
• 分子量: 465.463
• InChiKey: ZTNPNIPEXVPGCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  {3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine 生成 (-){3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine 、 (+){3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine
  参考文献：
  名称：

  Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

  摘要：

  The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H-3 receptor and the serotonin transporter is described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.034
• 作为产物：
  描述：

  1-[4-(3-piperidinopropoxy)phenyl]ethan-1-one 在 盐酸 、 sodium tetrahydroborate 、 PS-PPh3 、 偶氮二甲酸二苄酯 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 60.0h， 生成 {3-(3,4-dichloro-phenoxy)-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-propyl}-dimethyl-amine
  参考文献：
  名称：

  Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

  摘要：

  The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H-3 receptor and the serotonin transporter is described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.034

文献信息

• SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS
  申请人：Keith John M.

  公开号：US20080139564A1

  公开（公告）日：2008-06-12

  Certain substituted phenyl propyl amine compounds are histamine H 3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H 3 receptor- and/or serotonin-mediated diseases.

  某些取代苯基丙胺化合物是组胺H3受体和/或血清素转运体调节剂，可用于治疗组胺H3受体和/或血清素介导的疾病。
• WO2008/64036
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS<br/>[FR] PHÉNYLE PROPYLE AMINES SUBSTITUÉES UTILES EN TANT QUE RÉCEPTEUR H3 DE L'HISTAMINE ET MODULATEURS DES TRANSPORTEURS DE LA SÉROTONINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2008064036A1

  公开（公告）日：2008-05-29

  [EN] Certain substituted phenyl propyl amine compounds are histamine H₃ receptor and/or serotonin transporter modulators useful in the treatment of histamine H₃ receptor- and/or serotonin-mediated diseases.
  [FR] La présente invention concerne des composés à base de phényle propyle amines substituées qui sont des récepteurs d'histamine H3 et/ou des modulateurs des transporteurs de la sérotonine utiles dans le traitement de maladies médiées par le récepteur H3 de l'histamine et/ou de la sérotonine.
• Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity
  作者：Emily M. Stocking、Jennifer M. Miller、Ann J. Barbier、Sandy J. Wilson、Jamin D. Boggs、Heather M. McAllister、Jiejun Wu、Timothy W. Lovenberg、Nicholas I. Carruthers、Ronald L. Wolin

  DOI：10.1016/j.bmcl.2007.03.034

  日期：2007.6

  The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H-3 receptor and the serotonin transporter is described. (C) 2007 Elsevier Ltd. All rights reserved.