2-氯癸烷 | 1002-56-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 2-氯癸烷
• 英文名称: 2-chlorodecane
• 英文别名: 2-Chlor-decan；2-Decylchlorid
• CAS: 1002-56-8
• 化学式: C₁₀H₂₁Cl
• 分子量: 176.73
• InChiKey: OOZCPPCMBPSCDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  105 °C(Press: 10 Torr)
• 密度：
  0.860±0.06 g/cm3(Predicted)
• 保留指数：
  1215

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-氯癸烷 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 2.0h， 以75%的产率得到癸烷
  参考文献：
  名称：

  Control of the free radical reaction by dynamic coordination: unique reactivity of pyridylethyl-substituted tin hydrides

  摘要：

  具有一个或两个吡啶基的锡氢化物在自由基条件下还原烷基卤化物时表现出独特的反应活性，表明分子内配位在自由基反应控制中的潜力。

  DOI：

  10.1039/a903795k
• 作为产物：
  描述：

  正癸烯 在 盐酸 、 silica gel 作用下， 以 水 为溶剂， 反应 24.0h， 以88%的产率得到2-氯癸烷
  参考文献：
  名称：

  在无有机溶剂的条件下使用氢卤酸进行硅胶介导的未活化烯烃的氢卤化反应

  摘要：

  在无有机溶剂的条件下，使用35％盐酸进行硅胶介导的未活化烯烃的氢氯化反应，得到了相应的氯化物，收率很高。使用47％氢溴酸或55％氢碘酸进行氢溴化或氢碘化分别得到相应的卤化物。硅胶可以循环使用五次，而不会造成任何明显的活性损失。

  DOI：

  10.1016/j.tetlet.2018.10.043

文献信息

• Chlorination of hydrocarbons with CCl4 catalyzed by complexes of Mn, Mo, V, Fe
  作者：R. I. Khusnutdinov、N. A. Shchadneva、A. R. Bayguzina、T. M. Oshnyakova、Yu. Yu. Mayakova、U. M. Dzhemilev

  DOI：10.1134/s1070428013110018

  日期：2013.11

  Catalytic chlorination of alkanes, cycloalkanes, and adamantane utilizing tetrachloromethane as the source of chlorine and applying catalysts containing manganese, molybdenum, vanadium, and iron activated with nitrile ligands, alcohols, and water was fulfilled. The optimum ratios of catalysts and reagents and the best reaction conditions were found for selective synthesis of chlorine-substituted hydrocarbons

  实现了利用四氯甲烷作为氯源对烷烃，环烷烃和金刚烷的催化氯化反应，并应用了含有经锰配体，醇和水活化的锰，钼，钒和铁的催化剂。发现了选择性合成氯取代烃衍生物的最佳催化剂和试剂比例和最佳反应条件。
• Removal of chlorinated hydrocarbons from alkylsilanes
  申请人：DOW CORNING CORPORATION

  公开号：EP0331123A2

  公开（公告）日：1989-09-06

  A process for reducing the chlorocarbon content of alkylsilanes is described. The process comprises (A) contacting crude alkylsilanes, containing as a minor portion chlorocarbons and a hydrogen-containing silane with a catalyst; wherein the catalyst is a sufficient amount of an effective Lewis acid forming material; (B) facilitating the reaction of the chlorocarbons with the hydrogen-containing silane in contact with the catalyst to convert the chloro­carbons to a linear or branched alkanes; (C) separating catalyst from the alkylsilanes and alkanes; and (D) recovering alkylsilanes with lowered chlorocarbon content.

  描述了一种减少烷基硅烷中碳氯含量的工艺。该工艺包括：(A) 将含有少量碳酰氯和含氢硅烷的粗烷基硅烷与催化剂接触；其中催化剂是足量的有效路易斯酸形成材料；(B) 促进碳酰氯与含氢硅烷在与催化剂接触时发生反应，将碳酰氯转化为线性或支链烷烃；(C) 从烷基硅烷和烷烃中分离催化剂；(D) 回收碳酰氯含量降低的烷基硅烷。
• Method for redistribution and purification of methylsilanes
  申请人：DOW CORNING CORPORATION

  公开号：EP0743315A2

  公开（公告）日：1996-11-20

  A redistribution process for enriching a low-boiling methylsilane mixture in a methylchlorosilane selected from dimethylhydrochlorosilane and trimethylchlorosilane. The process comprises contacting a low-boiling methylsilane mixture, resulting from the contact of methyl chloride with silicon, with alumina under non-equilibrium conditions at a temperature greater than 150°C. we have surprisingly found that the concentrations of dimethylhydrochlorosilane and trimethylchlorosilane reach maximum levels under non-equilibrium conditions occurring at a temperature greater than 150°C. The process is also useful for facilitating the removal of olefin and chlorocarbon organic contaminants from the low-boiling methylsilane mixture.

  一种使低沸点甲基硅烷混合物富含选自二甲基氢氯硅烷和三甲基氯硅烷的甲基氯硅烷的再分配工艺。我们惊奇地发现，在温度高于 150°C 的非平衡条件下，二甲基氢氯硅烷和三甲基氯硅烷的浓度达到最大值。该工艺还有助于从低沸点甲基硅烷混合物中去除烯烃和碳酰氯有机污染物。
• Removal of chlorocarbons from organochlorosilanes
  申请人：DOW CORNING CORPORATION

  公开号：EP0903352A2

  公开（公告）日：1999-03-24

  A process for reducing the chlorocarbon content of a mixture comprising an organochlorosilane, a chlorocarbon and a hydrosilane. This process comprises contacting a mixture comprising as a major portion an organochlorosilane and as a minor portion a chlorocarbon and a hydrosilane with an alumina-zirconia cogel to effect formation of an organochlorosilane mixture having reduced chlorocarbon content. When said mixture is contacted with alumina-zirconia cogel the chlorocarbon reacts with the hydrosilane to form a hydrocarbon that is thereafter easily separated from the organochlorosilane. Surprisingly, our process improves chlorocarbon removal efficiency while maintaining high throughput rates.

  一种降低由有机氯硅烷、碳酰氯和氢硅烷组成的混合物中碳酰氯含量的工艺。该工艺包括将主要由有机氯硅烷、次要由碳酰氯和氢硅烷组成的混合物与氧化铝-氧化锆凝胶接触，以形成碳酰氯含量降低的有机氯硅烷混合物。当所述混合物与氧化铝-氧化锆凝胶接触时，碳酰氯与氢硅烷发生反应，形成碳氢化合物，此后，碳氢化合物很容易从有机氯硅烷中分离出来。令人惊讶的是，我们的工艺提高了碳酰氯的去除效率，同时还保持了较高的生产率。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。