(2,6-dichlorophenyl)(difluoromethyl)sulfane | 1150634-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,6-dichlorophenyl)(difluoromethyl)sulfane
• 英文别名: 1,3-Dichloro-2-[(difluoromethyl)sulfanyl]benzene；1,3-dichloro-2-(difluoromethylsulfanyl)benzene
• CAS: 1150634-70-0
• 化学式: C₇H₄Cl₂F₂S
• 分子量: 229.078
• InChiKey: FUXFDDJOZYQWTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二氯苯硫酚 、 二氟溴甲基三甲基硅烷 在 potassium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以99%的产率得到(2,6-dichlorophenyl)(difluoromethyl)sulfane
  参考文献：
  名称：

  Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF₂Br

  摘要：

  Two-in-one: Me3 SiCF2 Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance.

  DOI：

  10.1002/anie.201306703

文献信息

• AROMATIC POLYETHERS
  申请人：Moore David Roger

  公开号：US20090163692A1

  公开（公告）日：2009-06-25

  An aromatic polyether comprising structural units derived from a halosulfone sulfonate having structure (I): wherein R 1 is a C 3 -C 25 aromatic radical, a C 3 -C 25 cycloaliphatic radical, or a C 1 -C 10 aliphatic radical; M is hydrogen or a charge balancing cation; Y 1 is independently at each occurrence a halogen; “t” is an integer having a value of 1 or 2; “s” is an integer having a value 0 to 3, “b” is an integer having a value 1 to 4; and “c” is an integer having a value 1 to 20. Also provided are methods of preparing the aromatic polyethers, and compositions including the aromatic polyethers.

  一种芳香族聚醚，包括由具有结构（I）的卤代磺酸酯衍生的结构单元，其中 R1 是 C3-C25 芳香基团、C3-C25 环状脂肪族基团或 C1-C10 脂肪基团；M 是氢或平衡电荷的阳离子；Y1 独立地在每次出现时是卤素；“t” 是一个整数，取值为1或2；“s” 是一个整数，取值为0到3，“b” 是一个整数，取值为1到4；“c” 是一个整数，取值为1到20。还提供了制备芳香族聚醚的方法以及包括芳香族聚醚的组合物。
• Radical Difluororomethylation of Thiols with Difluoromethylphosphonium Triflate under Photoredox Catalysis
  作者：Yang Ran、Qing-Yu Lin、Xiu-Hua Xu、Feng-Ling Qing

  DOI：10.1021/acs.joc.7b01041

  日期：2017.7.21

  A convenient, visible light-induced radical difluoromethylation of aryl-, heteroaryl-, and alkylthiols with difluoromethyltriphenylphosphonium triflate was developed to afford various difluoromethyl thioethers in moderate to excellent yields. The key reaction features include the use of a readily available CF2H radical source, mild reaction conditions, and excellent chemoselective "thiol-difluoromethylation.
• <i>N</i>-Tosyl-<i>S</i>-difluoromethyl-<i>S</i>-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles
  作者：Wei Zhang、Fei Wang、Jinbo Hu

  DOI：10.1021/ol900567c

  日期：2009.5.21

  The first alpha-difluoromethyl sulfoximine compound, 2, was successfully prepared by using the copper(II)-catalyzed nitrene transfer reaction. Compound 2 was found to be a novel and efficient difluoromethylation reagent for transferring the CF2H group to S-, N-, and C-nucleophiles. Deuterium-labeling experiments suggest that a difluorocarbene mechanism is involved in the current difluoromethylation reactions.
• Synthesis of<i>gem</i>-Difluorocyclopropa(e)nes and O<i>-</i>, S<i>-</i>, N<i>-</i>, and P-Difluoromethylated Compounds with TMSCF₂Br
  作者：Lingchun Li、Fei Wang、Chuanfa Ni、Jinbo Hu

  DOI：10.1002/anie.201306703

  日期：2013.11.18

  Two-in-one: Me3 SiCF2 Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance.