1,8-dithio-octanedioic acid | 49861-19-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代酸
• 英文名称: 1,8-dithio-octanedioic acid
• 英文别名: 1,8-Dithio-octandisaeure；Octanebis(thioic) acid；octanebis(thioic S-acid)
• CAS: 49861-19-0
• 化学式: C₈H₁₄O₂S₂
• 分子量: 206.33
• InChiKey: OITULTNTMHGRLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  36.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,8-二辛酰氯 在 吡啶 、 硫化氢 作用下， 生成 1,8-dithio-octanedioic acid
  参考文献：
  名称：

  Sunner, Svensk Kemisk Tidskrift, 1950, vol. 62, p. 204,208

  摘要：

  DOI：

文献信息

• Thioic acids as building block for polythioesters
  申请人：DSM IP Assets B.V.

  公开号：EP2199281A1

  公开（公告）日：2010-06-23

  The present invention relates to thioic acids according to formula I, suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (-CH2-)2, -CH2-O-CH2- or (-CH2-)3 ; if R1=(-CH2-)2 and X=O, R2 is chosen from a non-degradable polymer with a Mw>6000, a degradable polymer or oligomer, an aliphatic compound comprising at least 2 C atoms and a Mw<5000 or an aromatic compound comprising at least 2 aromatic rings; if R1=(-CH2-)2 and X=N or S or if R1=(-CH2-)3, R2 is chosen from a monomer, oligomer or polymer. If R1 = (-CH2-)2, R2 is preferably chosen from polyethyleneglycol (PEG) with a Mw>6000 or a degradable polymer or oligomer. If R1=(-CH2-)2 and X=N or S or if R1=(-CH2-)3, R2 is preferably chosen from a biodegradable oligomer or polymer chosen from poly (lactide) (PLLA), polyglycolide (PGA), co-oligomers or copolymers of PLA and PGA (PLGA), poly(anhydrides), poly(trimethylenecarbonates), poly(orthoesters), poly(dioxanones), poly(ε-caprolactones) (PCL) or polyesteramides.

  本发明涉及符合以下式I的硫酸，作为聚硫酯的构建块； 其中X为O、N或S，且 R1选择自(-CH2-)2、- -O- -或(- -)3； 如果R1=(- -)2且X=O，则R2选择自Mw>6000的不可降解聚合物、可降解聚合物或寡聚物、至少含有2个C原子且Mw<5000的脂肪族化合物或至少含有2个芳香环的芳香族化合物； 如果R1=(- -)2且X=N或S，或者R1=(- -)3，则R2选择自单体、寡聚物或聚合物。 如果R1=(- -)2，则R2优选选择自Mw>6000的聚乙二醇（PEG）或可降解聚合物或寡聚物。 如果R1=(- -)2且X=N或S，或者R1=(- -)3，则R2优选选择自可生物降解寡聚物或聚合物，选择自聚（乳酸）（PLLA）、聚乙醇酸（PGA）、PLA和PGA的共寡聚物或共聚物（PLGA）、聚（酸酐）、聚（三甲基碳酸酯）、聚（正交酯）、聚（二氧环己酮）、聚（ε-己内酯）（PCL）或聚酯酰胺。
• THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS
  申请人：Boerakker Mark Johannes

  公开号：US20110301288A1

  公开（公告）日：2011-12-08

  The present invention relates to thioic acids according to formula (II) suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (—CH 2 —) 2 , —CH 2 —O—CH 2 — or (—CH 2 —) 3 , R2 is preferably chosen from a biodegradable oligomer or polymer chosen from poly(lactide) (PLLA), polyglycolide (PGA), co-oligomers or copolymers of PLA and PGA (PLGA), poly(anhydrides), poly(trimethylenecarbonates), poly(orthoesters), poly(dioxanones), poly(ε-caprolactones) (PCL) or polyesteramides and n>1.

  本发明涉及符合式（II）的硫酸的使用作为聚硫酯的构建块；其中X为O、N或S，R1选自（—CH2—）2、— —O— —或（— —）3，R2优选选自可生物降解的寡聚物或聚合物，选自聚乳酸（PLLA）、聚乙二醇酸（PGA）、PLA和PGA（PLGA）的共寡聚物或共聚物、聚酸酐、聚三甲基碳酸酯、聚正酯、聚二噁烷酮、聚ε-己内酯（PCL）或聚酯酰胺，n>1。
• Polymers comprising thioester bonds
  申请人：Athanasius Dias Aylvin Jorge Angelo

  公开号：US20090156707A1

  公开（公告）日：2009-06-18

  This invention is in the field of polymer chemistry. More in particular it provides a method to produce polymers such as block copolymers or cross-linked networks that are suitable for medical applications. The invention also provides degradable materials that may degrade completely when used in the human or animal body, minimizing residual components that may be toxic or otherwise undesirable.

  这项发明是在聚合物化学领域。更具体地，它提供了一种生产适用于医疗应用的聚合物，例如嵌段共聚物或交联网络的方法。该发明还提供可降解材料，当在人体或动物体内使用时，可以完全降解，从而最大限度地减少可能具有毒性或其他不良影响的残留成分。
• Composition for optical materials and use thereof
  申请人：MITSUI TOATSU CHEMICALS, INCORPORATED

  公开号：EP0713105A2

  公开（公告）日：1996-05-22

  A composition for optical materials which comprises; (a) a component containing at least one polyisocyanate represented by the formula (1)         A(̵S-B-NCO)n   (1) wherein A is an alkanediyl group or an alkanetetrayl group which may contain a sulfur atom, or a dithianetetrayl group, and the alkanediyl group or the alkanetetrayl group may be substituted by a phenyl group; B is a methylene chain represented by (m is an integer of 1 to 4) which may contain a sulfur atom, and B's may be the same or different; and n is an integer of 2 or 4, and (b) a component containing at least one polythiol having two or more mercapto groups. The composition is useful to provide optical products such as plastic lenses, filters, substrates for recording media and optical fibers which have a very high refractive index and which are excellent in heat resistance.

  一种光学材料组合物，包括 (a) 一种含有至少一种由式（1）表示的多异氰酸酯的成分 A(̵S-B-NCO)n (1) 其中 A 是一个烷二基或一个烷四基，该烷二基或烷四基可含有一个硫原子，或 一个二硫四基，该烷二基或烷四基可被一个苯基取代； B 是一个亚甲基链，其代表式为 (m 为 1 至 4 的整数)，其中可含有一个硫原子，B 可以相同或不同；n 为 2 或 4 的整数，以及 (b) 含有至少一种具有两个或两个以上巯基的聚硫醇的成分。该组合物可用于提供具有极高折射率和优异耐热性的光学产品，如塑料透镜、滤光片、记录介质基板和光纤。
• POLYOL COMPOUND, TRANSPARENT MOLDED OBJECTS, AND PROCESS FOR PRODUCING TRANSPARENT MOLDED OBJECT
  申请人：HOYA CORPORATION

  公开号：EP1640394A1

  公开（公告）日：2006-03-29

  A polyol compound characterized by being denoted by general formula (I). A transparent molded article obtained by polymerizing monomer components comprising the aforementioned polyol compound. A transparent molded article obtained by polymerizing monomer components comprising components (C) and (D). A method of manufacturing a transparent molded article, comprising casting a mixture of component (C) and component (D) into a casting mold and then polymerizing component (C) and component (D) to obtain a molded article.

  一种多元醇化合物，其特征是由通式（I）表示。通过聚合包含上述多元醇化合物的单体成分而获得的透明模塑制品。一种透明模塑制品，通过聚合包含组分（C）和（D）的单体组分而获得。一种制造透明模塑制品的方法，包括将组分(C)和组分(D)的混合物浇注到浇注模具中，然后聚合组分(C)和组分(D)以获得模塑制品。