1,10-dithio-decanedioic acid | 41476-09-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代酸
• 英文名称: 1,10-dithio-decanedioic acid
• 英文别名: 1,10-Dithio-decandisaeure；Decanebis(thioic) acid；decanebis(thioic S-acid)
• CAS: 41476-09-9
• 化学式: C₁₀H₁₈O₂S₂
• 分子量: 234.384
• InChiKey: OUADDINWGRXMJO-UHFFFAOYSA-N

物化性质

• 熔点：
  26 °C
• 沸点：
  354.1±25.0 °C(Predicted)
• 密度：
  1.085±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  36.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,10-dithio-decanedioic acid 、 环己烯 生成 1,10-dithio-decanedioic acid S,S'-dicyclohexyl ester
  参考文献：
  名称：

  Cunneen, Journal of Applied Chemistry, 1952, vol. 2, p. 353,355

  摘要：

  DOI：
• 作为产物：
  描述：

  癸二酰氯 在 吡啶 、 硫化氢 作用下， 生成 1,10-dithio-decanedioic acid
  参考文献：
  名称：

  Sunner, Svensk Kemisk Tidskrift, 1950, vol. 62, p. 204,208

  摘要：

  DOI：

文献信息

• Thioic acids as building block for polythioesters
  申请人：DSM IP Assets B.V.

  公开号：EP2199281A1

  公开（公告）日：2010-06-23

  The present invention relates to thioic acids according to formula I, suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (-CH2-)2, -CH2-O-CH2- or (-CH2-)3 ; if R1=(-CH2-)2 and X=O, R2 is chosen from a non-degradable polymer with a Mw>6000, a degradable polymer or oligomer, an aliphatic compound comprising at least 2 C atoms and a Mw<5000 or an aromatic compound comprising at least 2 aromatic rings; if R1=(-CH2-)2 and X=N or S or if R1=(-CH2-)3, R2 is chosen from a monomer, oligomer or polymer. If R1 = (-CH2-)2, R2 is preferably chosen from polyethyleneglycol (PEG) with a Mw>6000 or a degradable polymer or oligomer. If R1=(-CH2-)2 and X=N or S or if R1=(-CH2-)3, R2 is preferably chosen from a biodegradable oligomer or polymer chosen from poly (lactide) (PLLA), polyglycolide (PGA), co-oligomers or copolymers of PLA and PGA (PLGA), poly(anhydrides), poly(trimethylenecarbonates), poly(orthoesters), poly(dioxanones), poly(ε-caprolactones) (PCL) or polyesteramides.

  本发明涉及符合以下式I的硫酸，作为聚硫酯的构建块； 其中X为O、N或S，且 R1选择自(-CH2-)2、- -O- -或(- -)3； 如果R1=(- -)2且X=O，则R2选择自Mw>6000的不可降解聚合物、可降解聚合物或寡聚物、至少含有2个C原子且Mw<5000的脂肪族化合物或至少含有2个芳香环的芳香族化合物； 如果R1=(- -)2且X=N或S，或者R1=(- -)3，则R2选择自单体、寡聚物或聚合物。 如果R1=(- -)2，则R2优选选择自Mw>6000的聚乙二醇（PEG）或可降解聚合物或寡聚物。 如果R1=(- -)2且X=N或S，或者R1=(- -)3，则R2优选选择自可生物降解寡聚物或聚合物，选择自聚（乳酸）（PLLA）、聚乙醇酸（PGA）、PLA和PGA的共寡聚物或共聚物（PLGA）、聚（酸酐）、聚（三甲基碳酸酯）、聚（正交酯）、聚（二氧环己酮）、聚（ε-己内酯）（PCL）或聚酯酰胺。
• Polymers comprising thioester bonds
  申请人：Athanasius Dias Aylvin Jorge Angelo

  公开号：US20090156707A1

  公开（公告）日：2009-06-18

  This invention is in the field of polymer chemistry. More in particular it provides a method to produce polymers such as block copolymers or cross-linked networks that are suitable for medical applications. The invention also provides degradable materials that may degrade completely when used in the human or animal body, minimizing residual components that may be toxic or otherwise undesirable.

  这项发明是在聚合物化学领域。更具体地，它提供了一种生产适用于医疗应用的聚合物，例如嵌段共聚物或交联网络的方法。该发明还提供可降解材料，当在人体或动物体内使用时，可以完全降解，从而最大限度地减少可能具有毒性或其他不良影响的残留成分。
• Thiol and sulfur-containing O-(meth)acrylate counpounds and use thereof
  申请人：——

  公开号：US20010044555A1

  公开（公告）日：2001-11-22

  A sulfur-containing O-(meth)acrylate compound of the following formula (1) is useful as a starting material for a resin composition used in optical applications such as a lens; 1 wherein R represents hydrogen atom or methyl group; l represents an integer from 1 to 3; B is 2 when B is 3 n is 2; m is 1 or 2; A is selected from the following groups: 4 wherein m represents 1 or 2; each ring may be substituted by one or more alkyl, alkylthio or alkoxy groups having 1 or 2 carbon atoms; p and q are 0 or 1, while m is 1 when p is 1; when B is 5 n is 1; m is 2 or 3; A is selected from the following groups: —(CH 2 ) r —S—(CH 2 ) r —, —(CH 2 ) r —S—S—(CH 2 ) r —, —(CH 2 ) r —S—(CH 2 ) s —S—(CH 2 ) r — and 6 wherein r and s are an integer from 1 to 3; when B is 7 n is 1; m is 2; A is selected from the following groups: —(CH 2 ) r —S—(CH 2 ) r —, —(CH 2 ) r —S—S—(CH 2 ) r — and —(CH 2 ) r —S—(CH 2 ) s —S—(CH 2 ) r — wherein r and s are an integer from 1 to 3.

  下式（1）的含硫 O-（甲基）丙烯酸酯化合物可用作光学应用（如透镜）中所用树脂组合物的起始原料； 1 其中 R 代表氢原子或甲基； l 代表 1 至 3 的整数； B 是 2 当 B 为 3 n 为 2；m 为 1 或 2；A 选自以下基团： 4 其中 m 代表 1 或 2；每个环可被一个或多个具有 1 或 2 个碳原子的烷基、烷硫基或 烷氧基取代；p 和 q 为 0 或 1，而当 p 为 1 时，m 为 1； 当 B 为 5 n 为 1；m 为 2 或 3；A 选自以下基团： -(CH 2 ) r -S-(CH 2 ) r -、-(CH 2 ) r -S-S-(CH 2 ) r -、-(CH 2 ) r -S-(CH 2 ) s -S-(CH 2 ) r - 和 6 其中 r 和 s 是 1 至 3 的整数； 当 B 为 7 n 为 1；m 为 2；A 选自以下基团： -(CH 2 ) r -S-(CH 2 ) r -、-(CH 2 ) r -S-S-(CH 2 ) r - 和-(CH 2 ) r -S-(CH 2 ) s -S-(CH 2 ) r - 其中 r 和 s 是 1 到 3 的整数。
• Intestinal permeability in adult patients with growth hormone deficiency
  作者：J. García-Arnés、C. Sierra、F. Tinahones、A. Monzón、M. J. López、N. Mazuecos、F. Soriguer、E. Valverde

  DOI：10.1007/bf03343817

  日期：2001.2

  Pathological disruption of the intestinal mucosa increases the paracellular pathway, leading to an increase in the penetration of large molecules. Since growth hormone (GH) has a trophic intestinal effect, we used a double marker test to enable examination of intestinal permeability, which reflects the state of integrity of the intestinal mucosa, We recruited 22 adult patients, mean age 54+/-13.3 years, with GH deficiency due to partial or total hypopituitarism. None had received GH treatment at any time, although they were all in optimized replacement therapy. A control group was composed of 19 healthy age-matched relatives. The intestinal permeability test was performed with lactulose (5 g) and mannitol (1 g) after an oral load of 100 mi of aqueous solution. The urinary lactu- lose/mannitol ratio and the percentages of lactulose and mannitol excreted were determined on a 5-h urine collection. There were no significant differences between the patients and the control group in the lactulose/mannitol ratio (0.087+/-0.059 vs 0.077+/-0.064, respectively) or in the urinary excretion percentages of lactulose (0.067+/-0.048% vs 0.073+/-0.070%, respectively) or mannitol (5.127+/-3.269% vs 5.068+/-2.985%, respectively). In conclusion, no increase in intestinal permeability was detected in patients with GH deficiency, so that in spite of the known trophic effects of GH on the epithelial crypt cells, there was no intestinal hyperpermeability in these patients. (C) 2001, Editrice Kurtis.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: S: SVol.4a/b, 1.3.11.5, page 300 - 301
  作者：

  DOI：——

  日期：——