4-Methyl-6.7-dihydro-thieno<3.2-c>pyridin | 30433-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 4-Methyl-6.7-dihydro-thieno<3.2-c>pyridin
• 英文别名: 6,7-dihydro-4-methyl-thieno[3,2-c]pyridine；4-methyl-6H,7H-thieno[3,2-c]pyridine；4-methyl-6,7-dihydrothieno[3,2-c]pyridine
• CAS: 30433-99-9
• 化学式: C₈H₉NS
• 分子量: 151.232
• InChiKey: HBVBACFEOQYFLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Methyl-6.7-dihydro-thieno<3.2-c>pyridin 在 palladium-carbon 甲醇乙酸乙酯 作用下， 以 邻二甲苯 为溶剂， 反应 34.0h， 以4-methylthieno[3, 2-c]pyridine (j-1) was obtained as brown liquid的产率得到4-甲基噻吩并[3,2-c]吡啶
  参考文献：
  名称：

  Thienopyridine derivatives useful in treating gastric ulcers

  摘要：

  提供一种化合物，其化学式为：##STR1## 其中R.sup.1为氢，C.sub.1-C.sub.5烷基，C.sub.1-C.sub.5烷氧基，C.sub.1-C.sub.5烷氧羰基，或三氟甲基；R.sup.2为氢，C.sub.1-C.sub.5烷氧羰基，C.sub.6-C.sub.12芳基氧羰基，C.sub.1-C.sub.5烷酰氧-C.sub.1-C.sub.5烷基，C.sub.1-C.sub.5烷氧羰酰氧-C.sub.1-C.sub.5烷基，C.sub.1-C.sub.5酰胺基-C.sub.1-C.sub.5烷基，2-羟基-1-C.sub.2-C.sub.5烯基，邻苯二甲酰亚胺基-C.sub.1-C.sub.5烷基，卤代-C.sub.1-C.sub.5烷氧羰基-C.sub.1-C.sub.5烷基，羟基-C.sub.1-C.sub.5烷基，C.sub.1-C.sub.5烷基硫基-C.sub.1-C.sub.5烷基，或C.sub.1-C.sub.5烷基亚磺酰基-C.sub.1-C.sub.5烷基；##STR2## m为0或1的整数；R.sup.3和R.sup.4每个都是氢，卤素，氰基，C.sub.1-C.sub.5烷基，氨基，C.sub.1-C.sub.5烷氧基，C.sub.6-C.sub.12芳基-C.sub.1-C.sub.5烷氧基，C.sub.1-C.sub.5烷氧羰基，氟-C.sub.1-C.sub.5烷氧基，C.sub.1-C.sub.5烷酰胺基或氨基甲酰基），或其盐，可用作抗溃疡剂。

  公开号：

  US04839365A1
• 作为产物：
  描述：

  噻吩乙胺 在 sodium hydroxide 、 phosphorus pentoxide 、 乙酸酐 、 xylene 、 三氯氧磷 作用下， 生成 4-Methyl-6.7-dihydro-thieno<3.2-c>pyridin
  参考文献：
  名称：

  Sulfur Analogs of Isoquinolines

  摘要：

  DOI：

  10.1021/ja01145a117

文献信息

• Construction of a Protoberberine Alkaloid Skeleton via the Palladium-Catalyzed α-Arylation–Amide Formation Cascade
  作者：Shaofeng Li、Hanyu Nie、Mengyan Duan、Wenfei Wang、Congjun Zhu、Chuanjun Song

  DOI：10.1021/acs.orglett.1c03871

  日期：2021.12.17

  strategy of one-pot synthesis of protoberberine alkaloid derivatives via palladium-catalyzed cascade α-arylation and cyclization, which can afford the target molecules in moderate to excellent isolated yields using commercially available raw materials under solvent-free conditions. This protocol provides an efficient and convenient path to multisubstituted protoberberine derivatives. In addition, it can

  在这项工作中，我们报告了通过钯催化的级联α-芳基化和环化一锅法合成原小檗碱衍生物的策略，该策略可以在无溶剂条件下使用市售原料以中等至优异的分离产率提供目标分子. 该协议为多取代的原小檗碱衍生物提供了一条高效便捷的途径。此外，它可以直接负担天然生物碱。
• Thienopyridine derivatives useful in treating gastric ulcers
  申请人：Shinogi & Co., Ltd.

  公开号：US04839365A1

  公开（公告）日：1989-06-13

  A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, or trifluoromethyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkoxycarbonyl, C.sub.6 -C.sub.12 aryloxycarbonyl, C.sub.1 -C.sub.5 alkanoyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxycarbonyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 acylamino-C.sub.1 -C.sub.5 alkyl, 2-hydroxy-1-C.sub.2 -C.sub.5 alkenyl, phthalimido-C.sub.1 -C.sub.5 alkyl, halogeno-C.sub.1 -C.sub.5 alkoxycarbonyl-C.sub.1 -C.sub.5 alkyl, hydroxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkylthio-C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkylsulfinyl-C.sub.1 -C.sub.5 alkyl; ##STR2## m is an integer of 0 or 1; R.sup.3 and R.sup.4 each is hydrogen, halogen, cyano, C.sub.1 -C.sub.5 alkyl, amino, C.sub.1 -C.sub.5 alkoxy, C.sub.6 -C.sub.12 aryl-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, fluoro-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

  提供的化合物的结构式为：##STR1##（其中R.sup.1为氢，C.sub.1 -C.sub.5烷基，C.sub.1 -C.sub.5烷氧基，C.sub.1 -C.sub.5烷氧羰基，或三氟甲基；R.sup.2为氢，C.sub.1 -C.sub.5烷氧羰基，C.sub.6 -C.sub.12芳基氧羰基，C.sub.1 -C.sub.5烷酰氧-C.sub.1 -C.sub.5烷基，C.sub.1 -C.sub.5烷氧羰氧-C.sub.1 -C.sub.5烷基，C.sub.1 -C.sub.5酰胺基-C.sub.1 -C.sub.5烷基，2-羟基-1-C.sub.2 -C.sub.5烯基，邻苯二甲酰胺基-C.sub.1 -C.sub.5烷基，卤代-C.sub.1 -C.sub.5烷氧羰基-C.sub.1 -C.sub.5烷基，羟基-C.sub.1 -C.sub.5烷基，C.sub.1 -C.sub.5烷硫基-C.sub.1 -C.sub.5烷基，或C.sub.1 -C.sub.5烷基亚砜基-C.sub.1 -C.sub.5烷基；##STR2##m为0或1的整数；R.sup.3和R.sup.4各自为氢，卤素，氰基，C.sub.1 -C.sub.5烷基，氨基，C.sub.1 -C.sub.5烷氧基，C.sub.6 -C.sub.12芳基-C.sub.1 -C.sub.5烷氧基，C.sub.1 -C.sub.5烷氧羰基，氟代-C.sub.1 -C.sub.5烷氧基，C.sub.1 -C.sub.5烷酰胺基，或羰胺基）或其盐，可用作抗溃疡药物。
• Synthesis of New Thienopyridine Derivatives by [3+2]- and [2+2]-Cycloaddition Reactions
  作者：Mátyás Milen、György Keglevich、Péter Ábrányi-Balogh、András Dancsó

  DOI：10.1055/s-0032-1316794

  日期：——

  Abstract The reaction of 6,7-dihydrothieno[3,2-c]pyridine derivatives with 1,3-dipoles, such as a nitrile oxides or nitrile imines, gave novel fused heterocycles. The Staudinger reaction of the starting material was also studied. This reaction was stereoselective and exclusively gave racemic cis-cycloadducts in which the thienopyridine core was fused with a β-lactam ring. The reaction of 6,7-dihydrothieno[3

  摘要 6,7-二氢噻吩并[3,2- c ]吡啶衍生物与1,3-偶极，如一氧化氮或腈亚胺的反应，得到了新颖的稠合杂环。还研究了起始材料的斯托丁格反应。该反应是立体选择性的，并且仅产生外消旋的顺式-环加合物，其中噻吩并吡啶核与β-内酰胺环稠合。 6,7-二氢噻吩并[3,2- c ]吡啶衍生物与1,3-偶极，如一氧化氮或腈亚胺的反应，得到了新颖的稠合杂环。还研究了起始材料的斯托丁格反应。该反应是立体选择性的，并且仅产生外消旋的顺式-环加合物，其中噻吩并吡啶核与β-内酰胺环稠合。
• Tricyclic pyridine derivatives and pharmaceutical compositions
  申请人：Hoffmann-La Roche Inc.

  公开号：US04735940A1

  公开（公告）日：1988-04-05

  Compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt of a compound of formula I which has one or more basic substituents, are described. The compounds of formula I possess pronounced muscle relaxant, sedative-hypnotic, anticonvulsive and anxiolytic properties and have low toxicity.

  描述了公式##STR1##的化合物或具有一个或多个碱性取代基的公式I的化合物的药学上可接受的酸加成盐。公式I的化合物具有明显的肌肉松弛、镇静催眠、抗惊厥和抗焦虑性质，并具有低毒性。
• Tricyclic pyridine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US05036066A1

  公开（公告）日：1991-07-30

  The compounds are of the class of bi- and tricyclic pyridone derivatives of the formula ##STR1## wherein the various substituent are as described in the specification, useful in the control of prevention of muscle tensions stress conditions, insomnia, anxiety states and/or convulsions.

  这些化合物属于双环和三环吡啶酮衍生物类，其化学式为##STR1##其中各种取代基如规范所述，可用于控制和预防肌肉紧张、压力状态、失眠、焦虑状态和/或惊厥。