4,4'-(pyrazine-2,5-diyl)dibenzonitrile | 55368-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-(pyrazine-2,5-diyl)dibenzonitrile
• 英文别名: 2,5-bis-(4'-cyanophenyl)-pyrazine；4,4'-pyrazine-2,5-diyl-bis-benzonitrile；4,4'-(2,5-Pyrazindiyl)-dibenzonitril；4-[5-(4-cyanophenyl)pyrazin-2-yl]benzonitrile
• CAS: 55368-77-9
• 化学式: C₁₈H₁₀N₄
• 分子量: 282.304
• InChiKey: JAXFDJOXKYYKDY-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C
• 沸点：
  528.4±50.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-(pyrazine-2,5-diyl)dibenzonitrile 以46%的产率得到
  参考文献：
  名称：

  DANN O.; FICK H.; PIETZNER B.; WALKENHORST E.; FERNBACH R.; ZEH D., J. LIEBIGS ANN. CHEM. , 1975, NO 1, 160-194

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-4'-氰基苯乙酮 生成 4,4'-(pyrazine-2,5-diyl)dibenzonitrile
  参考文献：
  名称：

  TANIGUTI, XIROSI;ISOMURA, KADZUAKI

  摘要：

  DOI：

文献信息

• Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates
  作者：Zhengwang Chen、Dongnai Ye、Guohai Xu、Min Ye、Liangxian Liu

  DOI：10.1039/c3ob41164h

  日期：——

  A highly efficient synthesis of a wide range of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in moderate to excellent yields with a broad substrate scope, including a variety of aromatic and aliphatic haloenol acetates.

  描述了一种高效合成多种2,5-二取代吡嗪的方法，该方法源自(Z)-β-卤烯醇醋酸酯。在便利的条件下进行反应，所产物具有优异的区域选择性，产率中等至优秀，并且适用范围广泛，包括多种芳香族和脂肪族卤烯醇醋酸酯。
• Linear dicationic terphenyls and their aza analogues as antiparasitic agents
  申请人：Tidwell R. Richard

  公开号：US20070232621A1

  公开（公告）日：2007-10-04

  Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.

  小说二价离子三苯基化合物及其氮杂环类似物。使用小说二价离子三苯基化合物及其氮杂环类似物对微生物感染进行作战的方法。合成小说二价离子三苯基化合物及其氮杂环类似物的过程。
• Teraryl components as antiparasitic agents
  申请人：The University of North Carolina at Chapel Hill

  公开号：US07964619B2

  公开（公告）日：2011-06-21

  Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR4. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

  本文披露了新型二阳离子的三苯基化合物及其氮杂环类似物，包括公式（IIe）的化合物：其中p和q均为0，每个A，Y和Z均为CR4。公式（IIe）的一个示例化合物为：与新型二阳离子的三苯基化合物及其氮杂环类似物一起，还包括用于对抗微生物感染（如寄生虫利什曼体属）的方法。本文还披露了合成新型二阳离子的三苯基化合物及其氮杂环类似物的过程，以及评估这些化合物作为潜在抗原虫剂的方法。
• Substituted pyridines as antiparasitic AZA teraryl compounds
  申请人：The University of North Carolina at Chapel Hill

  公开号：US08188121B2

  公开（公告）日：2012-05-29

  Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A1, Y1, and Z1 is N; Ar1 is phenylene; and Ar3 is a nitrogen-containing aromatic group. An exemplary compound of Formula (III) is:

  本文描述了用于对抗微生物感染的二阳离子三苯基化合物的新型氮杂脲类似物。这些化合物包括公式（III）中的化合物：其中A1，Y1和Z1中的一个是N；Ar1是苯基；Ar3是含氮芳香族基团。公式（III）的示例化合物为：
• NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS
  申请人：Tidwell Richard R.

  公开号：US20110257199A1

  公开（公告）日：2011-10-20

  Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.

  小说二元离子三苯基化合物及其氮杂环类似物。使用小说二元离子三苯基化合物及其氮杂环类似物对抗微生物感染的方法。合成小说二元离子三苯基化合物及其氮杂环类似物的过程。