2,4-Thiazolidinedione, 5-[(2-chloro-6-fluorophenyl)methylene]- | 141479-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2,4-Thiazolidinedione, 5-[(2-chloro-6-fluorophenyl)methylene]-
• 英文别名: 5-[(2-chloro-6-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione
• CAS: 141479-30-3
• 化学式: C₁₀H₅ClFNO₂S
• 分子量: 257.673
• InChiKey: WXXWPWROXLXBGE-UHFFFAOYSA-N

物化性质

• 密度：
  1.598±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-噻唑烷二酮 、 2-氯-6-氟-苯甲醛 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以80%的产率得到2,4-Thiazolidinedione, 5-[(2-chloro-6-fluorophenyl)methylene]-
  参考文献：
  名称：

  Sonochemistry: A good, fast and clean method to promote the synthesis of 5-arylidene-2,4-thiazolidinediones

  摘要：

  The efficient synthesis of sixteen 5-arylidene-2,4-thiazolidinediones by aldol condensation reaction of 2,4-thiazolidinedione, mono- and di-substituted arenealdehydes and KOH using ultrasound irradiation is reported. The desired compounds were obtained in a few min (10-30 min) with moderate to good yields (25-81%). (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2014.04.013

文献信息

• Sonochemistry: A good, fast and clean method to promote the synthesis of 5-arylidene-2,4-thiazolidinediones
  作者：Bruna B. Drawanz、Camila S. Ribeiro、Hellen G. Masteloto、Patrícia D. Neuenfeldt、Claudio M.P. Pereira、Geonir M. Siqueira、Wilson Cunico

  DOI：10.1016/j.ultsonch.2014.04.013

  日期：2014.9

  The efficient synthesis of sixteen 5-arylidene-2,4-thiazolidinediones by aldol condensation reaction of 2,4-thiazolidinedione, mono- and di-substituted arenealdehydes and KOH using ultrasound irradiation is reported. The desired compounds were obtained in a few min (10-30 min) with moderate to good yields (25-81%). (C) 2014 Elsevier B.V. All rights reserved.