(R)-t-butylmethylphosphino-di-t-butylphosphinomethane disulfide | 864956-80-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 英文名称: (R)-t-butylmethylphosphino-di-t-butylphosphinomethane disulfide
• 英文别名: (R)-2-[(di-t-butylphosphinothioylmethyl)methylphosphinothioyl]-2-methylpropane；Ditert-butyl-[[tert-butyl(methyl)phosphinothioyl]methyl]-sulfanylidene-lambda5-phosphane；ditert-butyl-[[tert-butyl(methyl)phosphinothioyl]methyl]-sulfanylidene-λ5-phosphane
• CAS: 864956-80-9
• 化学式: C₁₄H₃₂P₂S₂
• 分子量: 326.488
• InChiKey: MEMJQGUHTHHGBV-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  t-butylmethylphosphino-di-t-butylphosphinomethane diborane 在 三乙烯二胺 、 sulfur 作用下， 以 甲苯 为溶剂， 反应 16.0h， 生成 (R)-t-butylmethylphosphino-di-t-butylphosphinomethane disulfide 、 (S)-t-butylmethylphosphino-di-t-butylphosphinomethane disulfide
  参考文献：
  名称：

  One-ligand Catalytic Asymmetric Deprotonation of a Phosphine Borane: Synthesis of P-Stereogenic Bisphosphine Ligands

  摘要：

  A new protocol for the catalytic asymmetric deprotonation of a phosphine borane using s-BuLi and sub-stoichiometric quantities of chiral diamines is reported. The method involves three sequential additions of s-BuLi, and use of (-)-sparteine or the (+)-sparteine surrogate facilitates access to P-stereogenic phosphines with opposite configuration. The method is exemplified by the catalytic asymmetric synthesis of each enantiomer of precursors to QuinoxP*, trichickenfootphos, and Mini-PHOS.

  DOI：

  10.1021/jo200708e

文献信息

• C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
  申请人：Bao Jian

  公开号：US20050228190A1

  公开（公告）日：2005-10-13

  Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C 1 -symmetric bisphosphine ligands bound to transition metals.

  通过对原生手性烯烃进行对映选择性加氢制备(S)-(+)-3-(氨甲基)-5-甲基己酸及其结构相关化合物的材料和方法已被披露。这些方法采用了新颖的手性催化剂，其中包括与过渡金属结合的C1对称双膦配体。
• C1-SYMMETRIC BISPHOSPHINE LIGANDS AND THEIR USE IN THE ASYMMETRIC SYNTHESIS OF PREGABALIN
  申请人：Warner-Lambert Company LLC

  公开号：EP1727620A1

  公开（公告）日：2006-12-06
• C1-Symmetric Bisphospine Ligands and Their Use in the Asymmetric Synthesis of Pregabalin
  申请人：Bao Jian

  公开号：US20090124820A1

  公开（公告）日：2009-05-14

  Materials and Methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C 1 -symmetric bisphosphine ligands bound to transition metals.
• [EN] C1-SYMMETRIC BISPHOSPHINE LIGANDS AND THEIR USE IN THE ASYMMETRIC SYNTHESIS OF PREGABALIN<br/>[FR] LIGANDS DE BISPHOSPHINE C1-SYMMETRIQUES ET LEUR UTILISATION DANS LA SYNTHESE ASYMETRIQUE DE PREGABALINE
  申请人：WARNER LAMBERT CO

  公开号：WO2005087370A1

  公开（公告）日：2005-09-22

  Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl­hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition metals.
• One-ligand Catalytic Asymmetric Deprotonation of a Phosphine Borane: Synthesis of <i>P</i>-Stereogenic Bisphosphine Ligands
  作者：Johan Granander、Francesco Secci、Steven J. Canipa、Peter O’Brien、Brian Kelly

  DOI：10.1021/jo200708e

  日期：2011.6.3

  A new protocol for the catalytic asymmetric deprotonation of a phosphine borane using s-BuLi and sub-stoichiometric quantities of chiral diamines is reported. The method involves three sequential additions of s-BuLi, and use of (-)-sparteine or the (+)-sparteine surrogate facilitates access to P-stereogenic phosphines with opposite configuration. The method is exemplified by the catalytic asymmetric synthesis of each enantiomer of precursors to QuinoxP*, trichickenfootphos, and Mini-PHOS.