DS00329 | 34945-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: DS00329
• 英文别名: 10-(2-nitro-benzenesulfonyl)-10H-phenothiazine；10-(2-Nitrophenyl)sulfonylphenothiazine
• CAS: 34945-72-7
• 化学式: C₁₈H₁₂N₂O₄S₂
• 分子量: 384.436
• InChiKey: GTJVRQHHDRFCNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吩噻嗪 、 邻硝基苯磺酰氯 在 吡啶 作用下， 生成 DS00329
  参考文献：
  名称：

  Synthesis and investigation of some 10-benzenesulfonylphenothiazine derivatives

  摘要：

  DOI：

  10.1007/bf00475717

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND THEIR USE AGAINST TUBERCULOSIS<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEUR UTILISATION CONTRE LA TUBERCULOSE
  申请人：UNIV CAPE TOWN

  公开号：WO2014080378A1

  公开（公告）日：2014-05-30

  Tricyclic derivatives of formula (1), wherein R1 may be an alkyl sulphonate or sulphonamide group, are useful as antimicrobial agents. The derivatives are optionally substituted wherein R2 is a hydrogen, a halogen, a substituted alkyl group, a thioether or an acetyl group; Y may be N, or C; X may be S, SO, SO2, N, O, CH2, C(O), CO2, NHCO, and ring B is a 6, 7 or an 8 membered cycloalkyl ring. The tricyclic derivatives, such as phenothiazine derivatives, may be used in treating tuberculosis, especially drug sensitive and resistant forms of tuberculosis. The derivatives of the invention may be used independently or in combination with known anti-tubercular drugs such as isoniazid, ethionamide and ethambutol, and the combination may be administered as a single dose, or as two independent dosages. The tricyclic derivatives may also be used for the manufacture of a medicament for treating tuberculosis.
• Synthesis and investigation of some 10-benzenesulfonylphenothiazine derivatives
  作者：V. S. Karpinskii、L. V. Konovalova

  DOI：10.1007/bf00475717

  日期：1971.7