1,2-dihydro-2-oxoquinoxaline-3-carboxamide | 90323-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,2-dihydro-2-oxoquinoxaline-3-carboxamide
• 英文别名: 2-(1H)-Quinoxalinone-3-carboxamide；3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid amide；3-Oxo-3,4-dihydro-chinoxalin-2-carbonsaeure-amid；3,4-Dihydro-3-oxo-chinoxalin-2-carbonsaeure-amid；2-Aminocarbonyl-3,4-dihydro-3-oxo-chinoxalin；3-Carbamoyl-1,2-dihydrochinoxalin-2-on；3-Oxo-3,4-dihydroquinoxaline-2-carboxamide；3-oxo-4H-quinoxaline-2-carboxamide
• CAS: 90323-01-6
• 化学式: C₉H₇N₃O₂
• 分子量: 189.173
• InChiKey: WAOATEWSYYCRLL-UHFFFAOYSA-N

物化性质

• 熔点：
  265 °C (decomp)
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-dihydro-2-oxoquinoxaline-3-carboxamide 在 一水合肼 、 硫脲 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 19.0h， 生成 2-hydrazinoquinoxaline-3-N-dimethylaminomethylenecarboxamide
  参考文献：
  名称：

  Geies; Kamal El-Dean; Moustafa, Pharmazie, 1997, vol. 52, # 6, p. 436 - 441

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Carbonitrile-2(1H)-quinoxalinthione 在 盐酸 作用下， 反应 5.0h， 生成 1,2-dihydro-2-oxoquinoxaline-3-carboxamide
  参考文献：
  名称：

  Mahgoub, S. A., Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 61, # 12, p. 151 - 160

  摘要：

  DOI：

文献信息

• [EN] QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION<br/>[FR] AMPLIFICATION DU SIGNAL D'ANALOGUES DE QUINONEMÉTHIDES
  申请人：VENTANA MED SYST INC

  公开号：WO2015124703A1

  公开（公告）日：2015-08-27

  Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

  本文披露了一种新型的醌甲烯类似物前体，以及使用该前体的方法和套件的实施例，用于检测生物样本中的一个或多个靶标。检测方法包括将样本与检测探针接触，然后将样本与包含酶的标记共轭物接触。酶与包含可检测标记的醌甲烯类似物前体相互作用，形成具有可检测标记的反应性醌甲烯类似物，该类似物与生物样本中的靶标近距离或直接结合。然后检测可检测标记。在某些实施例中，通过多个醌甲烯类似物前体与不同酶相互作用，无需酶去活化步骤即可检测多个靶标。
• HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE
  申请人：Motoki Kayoko

  公开号：US20110053933A1

  公开（公告）日：2011-03-03

  The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R 1 and R 2 independently represents a group such as a hydrogen atom or a halogen atom; R 3 represents a group such as a hydrogen atom; each of R 4 and R 5 independently represents a group such as a hydrogen atom, a halogen atom or a C 1-4 alkyl group; each of R 6 and R 7 independently represents a hydrogen atom or a C 1-4 alkyl group; X represents a group such as a C 3-10 cycloalkyl group, C 6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as —CO—, —O— or —NRa—, and Ra represents a group such as a hydrogen atom or a C 1-4 alkyl group.

  本发明提供了一种新型的羟基喹喔啉羧酰胺衍生物，可用于预防和/或治疗血液凝固障碍。该化合物由式(i)表示，或其药学上可接受的盐：其中，R1和R2各自独立地表示氢原子或卤素原子等基团；R3表示氢原子等基团；R4和R5各自独立地表示氢原子、卤素原子或C1-4烷基等基团；R6和R7各自独立地表示氢原子或C1-4烷基等基团；X表示C3-10环烷基、C6-10芳基或5-至10元杂环基等基团，该基团可以被选自取代基团α的取代基团所取代；Y表示—CO—、—O—或—NRa—等基团，其中Ra表示氢原子或C1-4烷基等基团。
• [EN] METHODS OF SEQUENCING BY SYNTHESIS USING A CONSECUTIVE LABELING SCHEME<br/>[FR] PROCÉDÉS DE SÉQUENÇAGE PAR SYNTHÈSE AU MOYEN D'UN SCHÉMA DE MARQUAGE CONSÉCUTIF
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021123074A1

  公开（公告）日：2021-06-24

  The present disclosure provides a method for sequencing target polynucleotide molecules. In some embodiments, the present disclosure provides a method of sequencing by synthesis where different subsets of nucleotide-conjugate complexes are sequentially formed and detected during each iterative extension of a plurality of nascent nucleic acid copy strands, where each nascent nucleic acid copy strand is complementary to one of a plurality of target polynucleotide molecules. In some embodiments, the plurality of target polynucleotide molecules are arrayed on a solid support.

  本公开提供了一种测序目标多核苷酸分子的方法。在某些实施例中，本公开提供了一种通过合成测序的方法，在每个迭代扩展多个新生核酸复制链的过程中，顺序形成和检测不同的核苷酸-结合物复合物的子集，其中每个新生核酸复制链与多个目标多核苷酸分子中的一个互补。在某些实施例中，多个目标多核苷酸分子被排列在固体支撑物上。
• Haptens, hapten conjugates, compositions thereof and method for their preparation and use
  申请人：Ventana Medical Systems, Inc.

  公开号：EP2442107A2

  公开（公告）日：2012-04-18

  A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.

  本文描述了一种进行多重诊断检测的方法，例如针对样品中两个或多个不同靶点的检测。其中一个实施方案包括用两个或两个以上特异性结合分子与样品接触，这些特异性结合分子与两个或两个以上不同的靶标特异性结合。这两种或两种以上特异性结合分子与不同的抗原共轭，其中至少一种抗原是噁唑、吡唑、噻唑、二硝基苯以外的硝基芳基化合物、苯并呋喃、三萜、脲、硫脲、类橙皮甙、香豆素、环木脂素、杂芳基、偶氮芳基或苯并二氮杂卓。样品与两种或两种以上可分别检测的不同抗链肽抗体接触。两种或多种不同的抗链肽抗体可与不同的可检测标签连接。
• METHOD FOR DETECTION OF HYDROXYMETHYLATION STATUS
  申请人：Oslo Universitetssykehus HF

  公开号：EP3904533A1

  公开（公告）日：2021-11-03

  The present invention relates to methods for the detection of 5-hydroxymethylcytosine (5hmC) by diluting the 5 hmC concentration while maintaining the methylation using a methyltransferase enzyme, e.g. DNMT1, DNMT2 or DNMT3. The method may be used in the detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.

  本发明涉及通过使用甲基转移酶（如 DNMT1、DNMT2 或 DNMT3）在保持甲基化的同时稀释 5 hmC 浓度来检测 5-羟甲基胞嘧啶（5hmC）的方法。该方法可用于检测基因组 DNA（如哺乳动物基因组 DNA）中的 5hmC。