1-Fluoro-4-(2-methylcyclopropyl)benzene | 344747-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Fluoro-4-(2-methylcyclopropyl)benzene
• CAS: 344747-79-1
• 化学式: C₁₀H₁₁F
• 分子量: 150.19
• InChiKey: ANZUFFHVZZRJEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (η5-Cp)iron(CO)2-α-methoxyethyl 、 三氟甲磺酸三甲基硅酯 、 4-氟苯乙烯 生成 1-Fluoro-4-(2-methylcyclopropyl)benzene
  参考文献：
  名称：

  BROOKHART, M.;KEGLEY, S. E.;HUSK, G. R., ORGANOMETALLICS, 1984, 3, N 4, 650-652

  摘要：

  DOI：

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR ACTIVITY AND/OR EXPRESSION AND USES THEREOF<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE L'ACTIVITÉ ET/OU DE L'EXPRESSION DU RÉCEPTEUR DES ANDROGÈNES ET UTILISATIONS CORRESPONDANTES
  申请人：UNIV ARIZONA

  公开号：WO2020123670A1

  公开（公告）日：2020-06-18

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer) and other conditions characterized with androgen receptor activity and/or androgen receptor expression.

  这项发明属于药物化学领域。具体地说，该发明涉及一类新型小分子，其具有哌嗪（或类似）结构，能够作为雄激素受体活性的拮抗剂，并且它们被用作治疗癌症（例如去势抵抗性前列腺癌）和其他与雄激素受体活性和/或雄激素受体表达相关的疾病的治疗药物。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• BIVALENT INHIBITORS OF IAP PROTEINS AND THERAPEUTIC METHODS USING THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20140057924A1

  公开（公告）日：2014-02-27

  Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed.

  抑制IAP蛋白质的抑制剂和含有这些抑制剂的组合物被披露。还披露了使用IAP蛋白质抑制剂治疗疾病和状况的方法，其中抑制IAP蛋白质提供益处，如癌症等。
• BISDIAZABICYCLO COMPOUND FOR TREATING AND/OR PREVENTING HEPATITIS VIRUS-RELATED DISEASES OR DISORDERS
  申请人：Jiangsu Ascentage Biomed Development Inc.

  公开号：EP3715349A1

  公开（公告）日：2020-09-30

  Disclosed are a bisdiazabicyclo compound for treating and/or preventing hepatitis virus-related diseases or disorders, a method for treating and/or preventing hepatitis virus-related diseases or disorders by using the bisdiazabicyclo compound, and a use of the bisdiazabicyclo compound in the preparation of a drug for treating and/or preventing hepatitis virus-related diseases or disorders, and/or eliminating or mitigating hepatitis virus-related diseases or disorders.

  本发明公开了一种用于治疗和/或预防肝炎病毒相关疾病或紊乱的双二氮杂双环化合物，一种通过使用该双二氮杂双环化合物治疗和/或预防肝炎病毒相关疾病或紊乱的方法，以及该双二氮杂双环化合物在制备治疗和/或预防肝炎病毒相关疾病或紊乱的药物中的用途，和/或消除或减轻肝炎病毒相关疾病或紊乱。
• BISDIAZABICYCLO COMPOUND FOR TREATMENT AND/OR PREVENTION OF HEPATITIS VIRUS-RELATED DISEASES OR DISORDERS
  申请人：JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC.

  公开号：US20210290594A1

  公开（公告）日：2021-09-23

  Disclosed are a bisdiazabicyclo compound for treating and/or preventing hepatitis virus-related diseases or disorders, a method for treating and/or preventing hepatitis virus-related diseases or disorders by using the bisdiazabicyclo compound, and a use of the bisdiazabicyclo compound in the preparation of a drug for treating and/or preventing hepatitis virus-related diseases or disorders, and/or eliminating or mitigating hepatitis virus-related diseases or disorders.