N-(4-chloroformylcyclohexylmethyl)-maleimide | 64987-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(4-chloroformylcyclohexylmethyl)-maleimide
• 英文别名: 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carbonyl chloride
• CAS: 64987-86-6
• 化学式: C₁₂H₁₄ClNO₃
• 分子量: 255.7
• InChiKey: MRNARDWKFREVMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium salt of N-hydroxysuccinimide 、 N-(4-chloroformylcyclohexylmethyl)-maleimide 生成 4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯
  参考文献：
  名称：

  YAMADA, IOSITSUGI;KOBAYASI, KADZUMI;ISIKAVA, EHJDZI

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(N-马来酰亚胺基甲基)环己基甲酸 生成 N-(4-chloroformylcyclohexylmethyl)-maleimide
  参考文献：
  名称：

  YAMADA, IOSITSUGI;KOBAYASI, KADZUMI;ISIKAVA, EHJDZI

  摘要：

  DOI：

文献信息

• Functionalized elastomer and method of making such an elastomer
  申请人：The Goodyear Tire & Rubber Company

  公开号：EP2803683A1

  公开（公告）日：2014-11-19

  A copolymer comprising: a polymeric backbone chain derived from a monomer comprising (i) at least one conjugated diene monomer or (ii) at least one a diene based elastomer selected from the group consisting of solution polymerized styrene butadiene rubber, emulsion polymerized styrene butadiene rubber, natural polyisoprene rubber, synthetic polyisoprene rubber, and polybutadiene, and, optionally, (iii) at least one vinyl aromatic monomer; and a polymeric side-chain bonded exclusively to a terminal end of the backbone chain is disclosed. The side-chain comprises a polymer derived from a monomer having a hydrogen bond donor site and a hydrogen bond acceptor site or derived from an N-substituted monoalkylacrylamide. Also, a method of making a functionalized elastomer is disclosed.

  一种共聚物，包括聚合物主链衍生自单体，该单体包括(i)至少一种共轭二烯单体或(ii)至少一种二烯基弹性体，该弹性体选自溶液聚合丁苯橡胶、乳液聚合丁苯橡胶、天然聚异戊二烯橡胶、合成聚异戊二烯橡胶和聚丁二烯组成的组，以及可选的(iii)至少一种乙烯基芳香族单体；以及聚合物侧链，该侧链专门键合到主链的末端。侧链包括由具有氢键供体位点和氢键受体位点的单体衍生的聚合物或由 N-取代单烷基丙烯酰胺衍生的聚合物。此外，还公开了一种制造功能化弹性体的方法。
• YAMADA, IOSITSUGI;KOBAYASI, KADZUMI;ISIKAVA, EHJDZI
  作者：YAMADA, IOSITSUGI、KOBAYASI, KADZUMI、ISIKAVA, EHJDZI

  DOI：——

  日期：——
• US20140343231A1
  申请人：——

  公开号：US20140343231A1

  公开（公告）日：2014-11-20
• COMPOSITIONS OF ANTIBODY CONSTRUCT-AGONIST CONJUGATES AND METHODS OF USE THEREOF
  申请人：OPI VI - IP HoldCo LLC

  公开号：US20170298139A1

  公开（公告）日：2017-10-19

  Various antibody construct compositions are disclosed. The compositions of antibody construct-immune stimulatory compound conjugates are also provided. Additionally provided are the methods of preparation and used of the antibody construct-immune stimulatory compound conjugates. This includes methods for treating disorders, such as cancer. A genus of STING agonist compounds and method of synthesis is also disclosed.
• US5849906A
  申请人：——

  公开号：US5849906A

  公开（公告）日：1998-12-15