3,4-dichloro-N-(3,4-dichlorophenyl)aniline | 1207319-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dichloro-N-(3,4-dichlorophenyl)aniline
• CAS: 1207319-21-8
• 化学式: C₁₂H₇Cl₄N
• 分子量: 307.006
• InChiKey: AAWLBMZIIKNAGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,4-二氯苯硼酸 在 盐酸羟胺 、 potassium carbonate 、 copper(I) bromide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以40%的产率得到3,4-dichloro-N-(3,4-dichlorophenyl)aniline
  参考文献：
  名称：

  羟胺盐酸盐在 Chan-Lam 反应中的应用：简单获得对称二芳胺

  摘要：

  描述了盐酸羟胺和芳基硼酸的 CuBr 催化偶联反应，为合成对称二芳基胺提供了一种简单有效的方法。该反应显示出良好的官能团耐受性。

  DOI：

  10.1055/s-0029-1218295

文献信息

• MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
  申请人：OPX Biotechnologies Inc.

  公开号：EP2689020A1

  公开（公告）日：2014-01-29
• [EN] MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS<br/>[FR] PRODUCTION MICROBIENNE DE PRODUITS CHIMIQUES, ET COMPOSITIONS, PROCÉDÉS ET SYSTÈMES ASSOCIÉS
  申请人：OPX BIOTECHNOLOGIES INC

  公开号：WO2012129450A1

  公开（公告）日：2012-09-27

  Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
• The Use of Hydroxylamine Hydrochloride in the Chan-Lam Reaction: A Simple Access to Symmetric Diarylamines
  作者：Jiang Cheng、Changfeng Zhou、Dongpeng Yang、Xiaofei Jia、Lixue Zhang

  DOI：10.1055/s-0029-1218295

  日期：2009.12

  A CuBr-catalyzed coupling reaction of hydroxylamine hydrochloride and arylboronic acids is described, providing a simple and efficient methodology for the synthesis of symmetric diaryl amines. The reaction shows good functional group tolerance.

  描述了盐酸羟胺和芳基硼酸的 CuBr 催化偶联反应，为合成对称二芳基胺提供了一种简单有效的方法。该反应显示出良好的官能团耐受性。