2-溴-4-二苯并呋喃甲腈 | 186821-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 2-溴-4-二苯并呋喃甲腈
• 英文名称: 2-Bromo-dibenzofuran-4-carbonitrile
• 英文别名: 2-Bromodibenzo[b,d]furan-4-carbonitrile；2-bromodibenzofuran-4-carbonitrile
• CAS: 186821-87-4
• 化学式: C₁₃H₆BrNO
• 分子量: 272.101
• InChiKey: GMZSTOQXPYGPCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-4-二苯并呋喃甲腈 、 N-甲基乙二胺 在 二硫化碳 作用下， 以93%的产率得到
  参考文献：
  名称：

  The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems

  摘要：

  A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium substituent. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00526-0
• 作为产物：
  描述：

  二苯并呋喃,2,4-二溴- 在 吡啶 、 正丁基锂 、 盐酸羟胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 2-溴-4-二苯并呋喃甲腈
  参考文献：
  名称：

  The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems

  摘要：

  A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium substituent. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00526-0

文献信息

• The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems
  作者：Joanne B. Laub、Mark L. Greenlee、Frank DiNinno、Joann L. Huber、Jon G. Sundelof

  DOI：10.1016/s0960-894x(99)00526-0

  日期：1999.10

  A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium substituent. (C) 1999 Elsevier Science Ltd. All rights reserved.