[3,5-Bis(phenylmethoxy)phenyl]methyl 2-bromo-2-methylpropanoate | 386701-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3,5-Bis(phenylmethoxy)phenyl]methyl 2-bromo-2-methylpropanoate
• 英文别名: [3,5-bis(phenylmethoxy)phenyl]methyl 2-bromo-2-methylpropanoate
• CAS: 386701-88-8
• 化学式: C₂₅H₂₅BrO₄
• 分子量: 469.375
• InChiKey: BROBHVPMWHOMBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴-2-甲基丙酰溴 、 3,5-二苄氧基苯甲醇 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以57.1%的产率得到[3,5-Bis(phenylmethoxy)phenyl]methyl 2-bromo-2-methylpropanoate
  参考文献：
  名称：

  Bis-ureidodeazapterin (Bis-DeAP) as a general route to supramolecular star polymers

  摘要：

  Supramolecular recognition unit Bis-DeAP, 1, containing two high affinity hydrogen-bonding acceptor-acceptor-donor-donor (AADD) arrays was designed to self-assemble into cyclic assemblies. It was prepared through a highly scalable synthesis and was further functionalized with 2-bromo-2-methylpropanoyl bromide and used to initiate the polymerization of methylmethacrylate (MMA). Bis-DeAPPMMA polymers quantitatively self-assembled into star polymers in toluene. In DMF Bis-DeAP-PMMA forms a mixture of star polymers and unassembled polymers. Bis-DeAP was also functionalized with polyethylene glycol (PEG) polymers. The Bis-DeAP-PEG polymers formed star polymers in DMF; however, higher molecular weight polymeric assembles that varied with concentration were observed in water. Mixing studies in toluene indicated that the self-assembled star polymers are kinetically stable and resist mixing even at elevated temperatures. In DMF, kinetically controlled structures are initially observed, however, mixing occurs at a faster rate and assembled star polymers show a decrease in polydispersity index (PDI) over time. In addition, Bis-DeAP functionalized PS and PMMA were mixed in DMF to generate a star copolymer through self-assembly. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.076

文献信息

• Bis-ureidodeazapterin (Bis-DeAP) as a general route to supramolecular star polymers
  作者：Eric M. Todd、Steven C. Zimmerman

  DOI：10.1016/j.tet.2008.05.076

  日期：2008.9

  Supramolecular recognition unit Bis-DeAP, 1, containing two high affinity hydrogen-bonding acceptor-acceptor-donor-donor (AADD) arrays was designed to self-assemble into cyclic assemblies. It was prepared through a highly scalable synthesis and was further functionalized with 2-bromo-2-methylpropanoyl bromide and used to initiate the polymerization of methylmethacrylate (MMA). Bis-DeAPPMMA polymers quantitatively self-assembled into star polymers in toluene. In DMF Bis-DeAP-PMMA forms a mixture of star polymers and unassembled polymers. Bis-DeAP was also functionalized with polyethylene glycol (PEG) polymers. The Bis-DeAP-PEG polymers formed star polymers in DMF; however, higher molecular weight polymeric assembles that varied with concentration were observed in water. Mixing studies in toluene indicated that the self-assembled star polymers are kinetically stable and resist mixing even at elevated temperatures. In DMF, kinetically controlled structures are initially observed, however, mixing occurs at a faster rate and assembled star polymers show a decrease in polydispersity index (PDI) over time. In addition, Bis-DeAP functionalized PS and PMMA were mixed in DMF to generate a star copolymer through self-assembly. (C) 2008 Elsevier Ltd. All rights reserved.