1-mercaptomethylisoquinoline | 74417-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-mercaptomethylisoquinoline
• 英文别名: Isoquinolin-1-ylmethanethiol
• CAS: 74417-36-0
• 化学式: C₁₀H₉NS
• 分子量: 175.254
• InChiKey: CAYDSCOKHMVXQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  13.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-mercaptomethylisoquinoline 在 三苯基氯甲烷 作用下， 以 二氯甲烷 、 乙酸酐 、 溶剂黄146 为溶剂， 反应 24.5h， 生成 8,9-benzo-3,4-phthaloylpyrrocoline
  参考文献：
  名称：

  Shah, J. N.; Tilak, B. D., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 1, p. 29 - 36

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(溴甲基)异喹啉 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 5.0h， 生成 1-mercaptomethylisoquinoline
  参考文献：
  名称：

  Shah, J. N.; Tilak, B. D., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 1, p. 29 - 36

  摘要：

  DOI：

文献信息

• Triazole Derivative and Use Thereof
  申请人：Kubo Keiji

  公开号：US20090105253A1

  公开（公告）日：2009-04-23

  The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R 1a , R 1b and R 2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R 3 is a group represented by the formula —NHCOR 4 , —NHSO 2 R 5 , —NHCON(R 6a )(R 6b ), —NHCOOR 7 or —CONHR 8 wherein R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R 1a and R 1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.

  本发明涉及一种含有式(I)所表示的化合物的凝血酶受体拮抗剂，其中R1a、R1b和R2分别是氢原子、可选取代的碳氢基团、可选取代的杂环基团或可选取代的烷氧基，R3是由式—NHCOR4、—NHSO2R5、—NHCON(R6a)(R6b)、—NHCOOR7或—CONHR8所表示的基团，其中R4、R5、R6a、R6b、R7和R8分别是氢原子、可选取代的碳氢基团、可选取代的杂环基团等，环A是单环芳香环，可选地进一步具有取代基，R1a和R1b可选择性地连接在一起形成可选取代的含氮非芳香杂环，或其盐或前药。本发明的凝血酶受体拮抗剂具有凝血酶受体（特别是PAR-1）拮抗作用，可用于预防或治疗PAR-1介导的病理状态或疾病。
• Polyepoxide curing by polymercaptans plus catalytic co-curing agents
  申请人：DIAMOND SHAMROCK CHEMICALS COMPANY

  公开号：EP0075827A2

  公开（公告）日：1983-04-06

  Extremely rapid ambient curing of polyepoxide resins and mixtures of polyepoxide resins and polyacrylate esters is achieved by use of a curing system composed of at least one polymercaptan and at least one catalytic co-curing agent which is the condensation product of: (a) aliphatic amine or substituted aliphatic amine containing at least one primary aliphatic amine group where the aliphatic moiety is ethylene or greater with (b) at least one amino acid, its corresponding lactam or other amide forming derivative. Optionally, known Lewis Base catalysts for the epoxy/ mercaptan reaction, such as tertiary amines, may also be used.

  通过使用由至少一种聚合物硫醇和至少一种催化助固化剂组成的固化体系，可实现聚环氧树脂以及聚环氧树脂和聚丙烯酸酯混合物的极速常温固化。 催化助固化剂是下列物质的缩合产物：(a) 脂肪族胺或含有至少一个伯脂肪族胺基团的取代脂肪族胺，其中脂肪族分子为乙烯或更大的乙烯基；(b) 至少一种氨基酸、其相应的内酰胺或其他酰胺形成衍生物。 也可选择使用已知的环氧/硫醇反应路易斯碱催化剂，如叔胺。
• TRIAZOLE DERIVATIVE AND THE USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1867331A1

  公开（公告）日：2007-12-19

  The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R1a, R1b and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R3 is a group represented by the formula -NHCOR4, -NHSO2R5, -NHCON(R6a) (R6b), -NHCOOR7 or -CONHR8 wherein R4, R5, R6a, R6b, R7 and R8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R1a and R1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.

  本发明涉及一种凝血酶受体拮抗剂，其中含有由式（I）代表的化合物 其中 R1a、R1b 和 R2 各为氢原子、任选取代的烃基、任选取代的杂环基团或任选取代的烷氧基，R3 为由式 -NHCOR4、-NHSO2R5、-NHCON(R6a) (R6b)、-NHCOOR7 或 -CONHR8 所代表的基团，其中 R4、R5、R6a、R6b、R7 和 R8 各为氢原子、任选取代的烃基、任选取代的杂环基等），环 A 是单环芳香环，任选进一步具有取代基，R1a 和 R1b 任选相互键合以形成任选取代的含氮非芳香杂环，或其盐或其原药。本发明的凝血酶受体拮抗剂具有凝血酶受体（尤其是 PAR-1）拮抗作用，可用于预防或治疗 PAR-1 介导的病理状态或疾病。
• Charging member, process cartridge, and electrophotographic image forming apparatus
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10036971B2

  公开（公告）日：2018-07-31

  Provided is a charging member that suppresses the occurrence of abnormal discharge under low temperature and low humidity. The charging member includes a support and a surface layer on the support, and the surface layer contains a compound represented by the following formula (a), (b), (c), or (d).

  本发明提供了一种在低温低湿条件下可抑制异常放电的充电元件。该充电元件包括支架和支架上的表面层，表面层含有下式（a）、（b）、（c）或（d）表示的化合物。
• Curing agent for polyepoxides, curable epoxy resin compositions, hardened products therefrom and process for curing a polyepoxide
  申请人：DIAMOND SHAMROCK CORPORATION

  公开号：EP0014745B1

  公开（公告）日：1983-05-25