(3,5-bistrifluoromethylphenoxy)acetic acid methyl ester | 87964-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-bistrifluoromethylphenoxy)acetic acid methyl ester
• 英文别名: Methyl 2-[3,5-bis(trifluoromethyl)phenoxy]acetate
• CAS: 87964-31-6
• 化学式: C₁₁H₈F₆O₃
• 分子量: 302.173
• InChiKey: AMLQVJSODCJJPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  3,5-二三氟甲基苯酚 生成 (3,5-bistrifluoromethylphenoxy)acetic acid methyl ester
  参考文献：
  名称：

  DAMICO, J. J.;SCHAFER, T. R.

  摘要：

  DOI：

文献信息

• [EN] FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS<br/>[FR] DÉRIVÉS AMIDES FLUORÉS ET LEURS UTILISATIONS COMME AGENTS THÉRAPEUTIQUES
  申请人：TRILLIUM THERAPEUTICS INC

  公开号：WO2017070795A1

  公开（公告）日：2017-05-04

  The present application relates to novel fluorinated amide derivatives of Formula (I), to processes for preparing them, pharmaceutical compositions containing them, and their use thereof in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain and other related CNS disorders.

  本申请涉及公式（I）的新型氟化酰胺衍生物，以及制备它们的过程、含有它们的药物组合物，以及它们在治疗或预防急性和/或慢性神经系统疾病，如精神病、癫痫、精神分裂症、阿尔茨海默病、认知障碍和记忆缺陷，以及慢性和急性疼痛和其他相关中枢神经系统疾病中的用途。
• 3,5-Bis (trifluoromethyl)phenoxy carboxylic acids and derivatives thereof
  申请人：Monsanto Company

  公开号：US04416687A1

  公开（公告）日：1983-11-22

  3,5-Bis (trifluoromethyl)phenoxy carboxylic acids and derivatives thereof have been found to reduce herbicidal injury of certain food crops, especially grain sorghum, due to the application thereto of herbicides that kill or control weeds that impede the yield of the crops.

  已经发现3,5-双(三氟甲基)苯氧羧酸及其衍生物可以减少某些食品作物，特别是谷物高粱，由于施用草甘膦类除草剂对作物产生的杀伤作用，因为这些除草剂可以杀死或控制杂草，从而阻碍作物的产量。
• Fluorinated amide derivatives and their uses as therapeutic agents
  申请人：Trillium Therapeutics Inc.

  公开号：US10604476B2

  公开（公告）日：2020-03-31

  The present application relates to novel fluorinated amide derivatives of Formula (I), to processes for preparing them, pharmaceutical compositions containing them, and their use thereof in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain and other related CNS disorders.

  本申请涉及式（I）的新型氟化酰胺衍生物、其制备工艺、含有它们的药物组合物，以及它们在治疗或预防急性和/或慢性神经系统疾病（如精神病、癫痫、精神分裂症、阿尔茨海默病、认知障碍和记忆缺陷）、慢性和急性疼痛及其他相关中枢神经系统疾病中的用途。
• DAMICO, J. J.;SCHAFER, T. R.
  作者：DAMICO, J. J.、SCHAFER, T. R.

  DOI：——

  日期：——
• FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS
  申请人：TRILLIUM THERAPEUTICS INC.

  公开号：US20180334425A1

  公开（公告）日：2018-11-22

  The present application relates to novel fluorinated amide derivatives of Formula (I), to processes for preparing them, pharmaceutical compositions containing them, and their use thereof in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain and other related CNS disorders.