ETHYL RED | 76058-33-8

• 物质功能分类: 生物化工 - 生化试剂 - 生物染料
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: ETHYL RED
• 英文别名: 2-(4-diethylamino-phenylazo)-benzoic acid；2-(4-Diaethylamino-phenylazo)-benzoesaeure；o-Aethylrot；Aethylrot；Benzoesaeure-(2 azo 4)-(N.N-diaethyl-anilin)；4'-Diaethylamino-azobenzol-carbonsaeure-(2)；Methyl Red
• CAS: 76058-33-8
• 化学式: C₁₇H₁₉N₃O₂
• 分子量: 297.357
• InChiKey: HBRCDTRQDHMTDA-VHEBQXMUSA-N

物化性质

• 熔点：
  135 °C
• 沸点：
  438.86°C (rough estimate)
• 密度：
  1.0871 (rough estimate)
• 溶解度：
  几乎不溶于水；微溶于乙醇，溶于苯
• 最大波长(λmax)：
  447nm

计算性质

• 辛醇/水分配系数(LogP)：
  4.65
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.26
• 氢给体数：
  1.0
• 氢受体数：
  4.0

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S24/25
• 危险类别码：
  R20/21,R32
• 海关编码：
  29270000

反应信息

• 作为反应物：
  描述：

  ETHYL RED 在 sulfur 作用下， 生成 2-amino-5-diethylamino-benzoic acid 、 苯胺
  参考文献：
  名称：

  Griess, Chemische Berichte, 1877, vol. 10, p. 528

  摘要：

  DOI：
• 作为产物：
  描述：

  o-Carboxybenzenediazonium 、 N,N-二乙基苯胺 在 丙酮 作用下， 生成 ETHYL RED
  参考文献：
  名称：

  DE409282

  摘要：

  公开号：

文献信息

• Oral care compositions with color changing indicator
  申请人：Sabnis W. Ram

  公开号：US20060222601A1

  公开（公告）日：2006-10-05

  The invention describes color changing toothpastes and mouthwashes which contains acid-base indicator(s) for interaction with the oral cavity to provide a color change indicative of treatment time.

  这项发明描述了含有酸碱指示剂的变色牙膏和漱口水，用于与口腔相互作用，以提供治疗时间的颜色变化指示。
• Alternative heterocycles for DNA recognition
  申请人：Dervan B. Peter

  公开号：US20050026174A1

  公开（公告）日：2005-02-03

  Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.

  提供了一种形成双链DNA与含有融合六元环的新寡聚物之间复合物的方法和组合物。通过选择适当的靶序列和寡聚物，可以获得具有高结合常数的含寡聚物-DNA的复合物。复合物的形成可用于特定双链DNA序列的识别，用于抑制基因转录，并作为抑制不需要的细胞增殖或调节特定基因表达的治疗方法。
• DNA-BINDING POLYMERS
  申请人：Dervan Peter B.

  公开号：US20090155202A1

  公开（公告）日：2009-06-18

  Methods and compositions are provided for forming complexes between dsDNA and novel DNA-binding polymers comprising N-terminal thiophene-containing moieties which exhibit selectivity for T-A base pairs. By appropriate choice of target sequences and DNA-binding polymers, complexes comprising polymer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.

  提供了一种形成双链DNA与含有N-末端噻吩基团的新型DNA结合聚合物之间的复合物的方法和组合物，这些聚合物对T-A碱基对具有选择性。通过适当选择目标序列和DNA结合聚合物，可以获得具有高结合常数的聚合物-DNA复合物。这些复合物的形成可用于特定双链DNA序列的识别，用于抑制基因转录，以及作为抑制不需要的细胞增殖或调控特定基因表达的治疗方法。
• WATER-SOLUBLE COMPOSITION, PRODUCTION METHOD FOR CURED PRODUCT THEREOF, AND CURED PRODUCT THEREOF, AND ACYL PHOSPHINATE
  申请人：ADEKA CORPORATION

  公开号：US20200032021A1

  公开（公告）日：2020-01-30

  Provided are: a water-soluble composition which has excellent storage stability and is adaptable to a wide range of light sources and capable of forming a highly fine pattern; a method of producing a cured product of the same; a cured product of the same; and an acylphosphinate. The water-soluble composition contains: an acylphosphinate (A) represented by Formula (I) below, wherein X 1 represents an aryl group having 6 to 15 carbon atoms; X 2 represents a linear alkyl group having 1 to 8 carbon atoms or the like; A m+ represents an alkali metal ion or the like; and m represents a number of 1 to 3; and a compound (B) having a group represented by Formula (II) below, wherein R 1 represents a hydrogen atom or the like; Z 1 represents an oxygen atom or the like; R 2 represents a hydrogen atom or the like; Z 2 represents an alkylene group having 1 to 6 carbon atoms; n represents a number of 0 to 30; * means a bond; and, when the compound (B) has plural groups represented by Formula (II), plural R 1′ s, Z 1′ s, Z 2′ s and n's are each optionally the same or different.

  提供了以下内容：一种水溶性组合物，具有优异的储存稳定性，适用于广泛的光源，并能形成高度精细的图案；一种制备该固化产品的方法；一种该固化产品；以及一种酰基膦酸酯。水溶性组合物包含：由下式（I）表示的酰基膦酸酯（A），其中X1表示具有6到15个碳原子的芳基基团；X2表示具有1到8个碳原子的线性烷基基团或类似物；Am+表示碱金属离子或类似物；m表示1到3的数字；以及具有下式（II）表示的基团的化合物（B），其中R1表示氢原子或类似物；Z1表示氧原子或类似物；R2表示氢原子或类似物；Z2表示具有1到6个碳原子的烷基基团；n表示0到30的数字；*表示一个键；当化合物（B）具有由式（II）表示的多个基团时，多个R1'、Z1'、Z2'和n'可以是任意相同或不同。
• Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA
  申请人：Phillion P. Dennis

  公开号：US20050009054A1

  公开（公告）日：2005-01-13

  The present invention is directed to the means by which to alter the binding affinity and/or specificity of a compound with a sequence of DNA in the minor groove of a double-strand thereof. More particularly, the present invention is directed to a synthetic and/or non-naturally occurring compound (e.g., an analog of a polyamide oligomer or polymer) which contains at least one hydrogen bond donor moiety and at least one hydrogen bond acceptor moiety, wherein the latter moiety or “building block” has a fused, bicyclic structure which is heteroaromatic, said structure having a heteroatom therein which acts as a hydrogen bond acceptor to bind guanine in the minor groove of the dsDNA sequence, and which is incapable of forming a tautomer. In one particular embodiment of the synthetic and/or non-naturally occurring compound, the fused, bicyclic structure occupies an initial or first terminal position within the compound.

  本发明涉及一种改变化合物与DNA双链中小沟的序列的结合亲和力和/或特异性的方法。特别地，本发明涉及一种合成和/或非自然存在的化合物（例如，聚酰胺寡聚物或聚合物的类似物），该化合物含有至少一个氢键供体基团和至少一个氢键受体基团，其中后者基团或“构建块”具有融合的、杂环芳香性的双环结构，该结构在其中具有作为氢键受体以结合双链DNA序列中的鸟嘌呤的杂原子，并且不能形成互变异构体。在合成和/或非自然存在的化合物的一个特定实施例中，融合的、双环结构占据化合物的初始或第一端位置。

表征谱图