2-溴-5-硝基吡啶-4-羧酸 | 1053655-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-5-硝基吡啶-4-羧酸
• 中文别名: 2-溴-5-硝基-4-吡啶羧酸
• 英文名称: 2-Bromo-5-nitropyridine-4-carboxylic acid
• CAS: 1053655-82-5
• 化学式: C6H3BrN2O4
• mdl: MFCD10699221
• 分子量: 247.0
• InChiKey: YISYYAZCRUHFBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

文献信息

• [EN] PHOSPHATE TRANSPORT INHIBITORS II<br/>[FR] INHIBITEURS DE TRANSPORT DE PHOSPHATE II
  申请人：LEO PHARMA AS

  公开号：WO2013082756A1

  公开（公告）日：2013-06-13

  Compounds according to formula (I) are useful in the treatment of phosphate homeostasis.

  根据式(I)的化合物在磷酸盐稳态治疗中很有用。
• PDE9 INHIBITOR AND USE THEREOF
  申请人：Nanjing Transthera Biosciences Co. Ltd.

  公开号：EP3689876A1

  公开（公告）日：2020-08-05

  The present invention falls within the technical field of medicine, and in particular relates to PDE9 inhibitor compounds as shown in formula (I) or pharmaceutically acceptable salts or stereoisomers thereof, and also relates to pharmaceutical preparations and pharmaceutical compositions of the compounds and the uses thereof. X1, X2, X3, X4, R1, R2, ring A, L and m are as defined in the description. The compounds can be used to prepare drugs for treating or preventing related diseases mediated by PDE9.

  本发明属于医药技术领域，尤其涉及式（I）所示的PDE9抑制剂化合物或其药学上可接受的盐或立体异构体，还涉及该化合物的药物制剂和药物组合物及其用途。X1、X2、X3、X4、R1、R2、环 A、L 和 m 如描述中所定义。这些化合物可用于制备治疗或预防由 PDE9 介导的相关疾病的药物。
• PDE9 inhibitor and use thereof
  申请人：Nanjing TransThera Biosciences Co. Ltd.

  公开号：US10889591B2

  公开（公告）日：2021-01-12

  The present invention falls within the technical field of medicine, and in particular relates to PDE9 inhibitor compounds as shown in formula (I) or pharmaceutically acceptable salts or stereoisomers thereof, and also relates to pharmaceutical preparations and pharmaceutical compositions of the compounds and the uses thereof. X1, X2, X3, X4, R1, R2, ring A, L and m are as defined in the description. The compounds can be used to prepare drugs for treating or preventing related diseases mediated by PDE9.

  本发明属于医药技术领域，尤其涉及式（I）所示的PDE9抑制剂化合物或其药学上可接受的盐或立体异构体，还涉及该化合物的药物制剂和药物组合物及其用途。X1、X2、X3、X4、R1、R2、环 A、L 和 m 如描述中所定义。这些化合物可用于制备治疗或预防由 PDE9 介导的相关疾病的药物。