2-溴-6-异丙氧基萘 | 200875-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-溴-6-异丙氧基萘
• 英文名称: 2-bromo-6-isopropoxynaphthalene
• 英文别名: 2-Bromo-6-(propan-2-yloxy)naphthalene；2-bromo-6-propan-2-yloxynaphthalene
• CAS: 200875-37-2
• 化学式: C₁₃H₁₃BrO
• mdl: MFCD18262542
• 分子量: 265.15
• InChiKey: QDZCGXCWASOOHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-溴-6-异丙氧基萘 在 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-(chloromethyl)-6-methoxynaphthalene
  参考文献：
  名称：

  C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

  摘要：

  A series of 1- and 4-(2-naphthylmethyl)-1H-imidazoles (3 and 4) has been synthesized and evaluated as C-17,C-20-lyase inhibitors. Several 6-methoxynaphthyl derivatives showed potent C-17,C-20-lyase inhibition, suppression of testosterone biosynthesis in rats and reduction in the weight of prostate and seminal vesicles in rats, whereas most of these compounds increased the liver weight after consecutive administrations. The effect on the liver weight was removed by incorporation of a hydroxy group and an isopropyl group at the methylene bridge, as seen in (S)-28d and (S)-42. Selectivity for C-17,C-20-lyase over 11beta-hydroxylase is also discussed, and (S)-42 was found to be a more than 260-fold selective inhibitor. Furthermore, (S)-42 showed a potent suppression of testosterone biosynthesis after a single oral administration in monkeys. These data suggest that (S)-42 may be a promising agent for the treatment of androgen-dependent prostate cancer. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.06.016
• 作为产物：
  描述：

  2-碘代丙烷 、 6-溴-2-萘酚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以77 %的产率得到2-溴-6-异丙氧基萘
  参考文献：
  名称：

  반응성 메소젠

  摘要：

  本发明涉及反应性液晶（RM）、包含所述RM的混合物及配方、由所述RM及其混合物得到的聚合物，以及在光学或电光组件和设备中所述RM、混合物和聚合物的应用。

  公开号：

  KR20240005069A

文献信息

• [EN] CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE LA CÉRAMIDE GALACTOSYLTRANSFÉRASE POUR LE TRAITEMENT DE MALADIES
  申请人：BIOMARIN PHARM INC

  公开号：WO2018118838A1

  公开（公告）日：2018-06-28

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物，以及使用这种化合物治疗或预防与酶神经鞘糖脂转移酶（CGT）相关的疾病或紊乱的方法，例如溶酶体贮积症。溶酶体贮积症的例子包括 Krabbe 病和白质变性白血病。
• [EN] INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION<br/>[FR] INDOLES UTILISES DANS LE TRAITEMENT D'INFLAMMATIONS
  申请人：BIOLIPOX AB

  公开号：WO2005123673A1

  公开（公告）日：2005-12-29

  There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

  提供一种化合物，其化学式为：(I)，其中X、R1、R2、R3、R4、R5和R6的含义如描述中所示，以及其药用盐，这些化合物在需要或希望抑制微粒体前列腺素E合成酶-1活性的疾病治疗中非常有用，特别是在炎症治疗中。
• 3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  申请人：Peters Dan

  公开号：US20090036456A1

  公开（公告）日：2009-02-05

  This invention relates to novel 3,9-diazabicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及一种新型的3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。在其他方面，本发明涉及使用这些化合物进行治疗的方法，以及包含本发明化合物的制药组合物。
• Indoles Useful in the Treatment of Inflammation
  申请人：Olofsson Kristofer

  公开号：US20070287715A1

  公开（公告）日：2007-12-13

  There is provided a compound of formula: (I), wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

  提供了一个公式为（I）的化合物，其中X，R1，R2，R3，R4，R5和R6在描述中有给定的含义，以及其药学上可接受的盐。这些化合物在治疗需要抑制微粒体前列腺素E合成酶-1活性的疾病，特别是在治疗炎症方面是有用的。
• NOVEL 3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  申请人：PETERS Dan

  公开号：US20100160333A1

  公开（公告）日：2010-06-24

  3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein R a and R b are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.

  3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。此外，本发明还涉及使用这些化合物进行治疗的方法以及包含这些化合物的制药组合物。3,9-二氮杂双环[3.3.1]壬烷衍生物的化学式如下，其中Ra和Rb如申请中所述。此外，还揭示了这些化合物的立体异构体和药用可接受盐。