6-(4-ethylphenyl)-2-(1,2-dihydro-10H-phenothiazin-10-ylmethyl)-4,5-dihydropyridazin-3(2H)-one | 1229037-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 6-(4-ethylphenyl)-2-(1,2-dihydro-10H-phenothiazin-10-ylmethyl)-4,5-dihydropyridazin-3(2H)-one
• 英文别名: 6-(4-Ethylphenyl)-2-(phenothiazin-10-ylmethyl)-4,5-dihydropyridazin-3-one
• CAS: 1229037-17-5
• 化学式: C₂₅H₂₃N₃OS
• 分子量: 413.543
• InChiKey: LHOOYFJZBRFRIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 吩噻嗪 、 6-(ethylphenyl)-2,3,4,5 tetrahydropyridazine-3-one 以 乙醇 为溶剂， 反应 24.0h， 以60%的产率得到6-(4-ethylphenyl)-2-(1,2-dihydro-10H-phenothiazin-10-ylmethyl)-4,5-dihydropyridazin-3(2H)-one
  参考文献：
  名称：

  Synthesis, characterization and antihypertensive activity of pyridazinone derivatives

  摘要：

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.

  DOI：

  10.1016/j.ejmech.2010.02.003

文献信息

• Synthesis, characterization and antihypertensive activity of pyridazinone derivatives
  作者：Anees A. Siddiqui、Ravinesh Mishra、Mohammad Shaharyar

  DOI：10.1016/j.ejmech.2010.02.003

  日期：2010.6

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.