2-Methyl-1-(p-trifluormethylphenyl)-butan | 14276-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-1-(p-trifluormethylphenyl)-butan
• 英文别名: 1-(2-Methylbutyl)-4-(trifluoromethyl)benzene
• CAS: 14276-93-8
• 化学式: C₁₂H₁₅F₃
• 分子量: 216.246
• InChiKey: BGNLLLBMZLKPNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  215.6±35.0 °C(Predicted)
• 密度：
  1.051±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-(三氟甲基)苯基)丙烷-2-酮 生成 2-Methyl-1-(p-trifluormethylphenyl)-butan
  参考文献：
  名称：

  The Migration Aptitude of Substituted Benzyl vs. Methyl in Carbonium Ion Reactions of the 2,2-Dimethyl-3-aryl-1-propyl System. The Question of Alkyl Participation¹

  摘要：

  DOI：

  10.1021/ja00976a022

文献信息

• [EN] SYNTHESIS OF OLIGOMERIC NEOLIGNANS AND THEIR USE<br/>[FR] SYNTHÈSE DE NÉOLIGNANES OLIGOMÈRES ET LEURS APPLICATIONS
  申请人：UNIV COLUMBIA

  公开号：WO2010074764A1

  公开（公告）日：2010-07-01

  Compounds having the structure formule (I) and their uses are described herein.

  具有结构式(I)的化合物及其用途在此描述。
• [EN] NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO<br/>[FR] NOUVEAUX COMPOSÉS, COMPOSITION PHARMACEUTIQUE ET PROCÉDÉS CORRESPONDANTS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010149684A1

  公开（公告）日：2010-12-29

  New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein R1, R2, R3, n, p, q, and Ar are as defined herein, including stereoisomers, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising a compound of this invention, as well as methods relating to the use thereof in a patient in need thereof.

  本发明公开了具有结构(I)的新化合物，其在患者中治疗各种与代谢相关的病症具有实用性：其中R1、R2、R3、n、p、q和Ar如本文所定义，包括立体异构体、溶剂合物和药学上可接受的盐。还公开了包含本发明化合物的药物组合物，以及关于其在有需要的患者中使用的方法。
• Aryl cyclopropyl-amino-isoquinolinyl amide compounds
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US10858339B2

  公开（公告）日：2020-12-08

  Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.

  本文提供的是芳基环丙基氨基异喹啉酰胺化合物。特别是，本公开提供的化合物可影响细胞中激酶的功能，并可作为治疗剂或与治疗剂一起使用。本公开的化合物可用于治疗多种疾病和病症，包括眼部疾病（如青光眼）、心血管疾病、以异常生长为特征的疾病（如癌症）以及炎症性疾病。本公开进一步提供了含有异喹啉酰胺化合物的组合物。
• COMT inhibiting methods and compositions
  申请人：LIEBER INSTITUTE FOR BRAIN DEVELOPMENT

  公开号：US10934283B2

  公开（公告）日：2021-03-02

  Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.

  本文提供了抑制 COMT 酶的化合物和包含这些化合物的药物组合物。本文还提供了使用本文所述化合物和药物组合物治疗各种精神和神经疾病的方法。
• Herbicides
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US10986838B2

  公开（公告）日：2021-04-27

  The present invention relates to herbicidally active pyridino-/pyrimidino-pyridine derivatives, as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants.

  本发明涉及具有除草活性的吡啶/嘧啶-吡啶衍生物，以及用于制备此类衍生物的工艺和中间体。本发明还涉及包含此类衍生物的除草组合物，以及此类化合物和组合物在控制不良植物生长方面的用途：特别是在控制有用植物作物中的杂草方面的用途。