bis-(1-[3]pyridyl-ethyl)-amine | 136469-80-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-(1-[3]pyridyl-ethyl)-amine
• 英文别名: Bis-(1-[3]pyridyl-aethyl)-amin；1-pyridin-3-yl-N-(1-pyridin-3-ylethyl)ethanamine
• CAS: 136469-80-2
• 化学式: C₁₄H₁₇N₃
• mdl: MFCD11160015
• 分子量: 227.309
• InChiKey: NETIJVPSPHJWLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-乙酰基吡啶 在 乙醇 、 盐酸羟胺 、 水 、 sodium acetate 、 镍 作用下， 100.0 ℃ 、19.61 MPa 条件下， 生成 bis-(1-[3]pyridyl-ethyl)-amine
  参考文献：
  名称：

  Preparation of Derivatives of Pyrrole and Pyridine by Hydrogenation

  摘要：

  DOI：

  10.1021/ja01236a025

文献信息

• Catalytic Asymmetric Reductive Condensation of N-H Imines: Synthesis of<i>C</i>₂-Symmetric Secondary Amines
  作者：Vijay N. Wakchaure、Benjamin List

  DOI：10.1002/anie.201608329

  日期：2016.12.19

  A highly diastereoselective and enantioselective Brønsted acid catalyzed reductive condensation of N−H imines was developed. This reaction is catalyzed by a chiral disulfonimide (DSI), uses Hantzsch esters as a hydrogen source, and delivers useful C2‐symmetric secondary amines.

  开发了一种高度非对映选择性和对映选择性的布朗斯台德酸催化的NH亚胺的还原缩合反应。该反应由手性二磺酰亚胺（DSI）催化，使用Hantzsch酯作为氢源，并提供有用的C 2对称仲胺。
• Effective Conversion of Heteroaromatic Ketones into Primary Amines via Hydrogenation of Intermediate Ketoximes
  作者：Christopher Borths、Kyle Baucom、Anil Guram

  DOI：10.1055/s-0034-1379538

  日期：——

  A process to access heteroaromatic primary amines from the corresponding heteroaromatic ketones has been developed. A broad range of previously reported methods to convert ketones to primary amines was examined on heterocyclic ketones without success, including Leuckart–Wallach conditions, borane reductions, and transition-metal-catalyzed hydrogenations. Unique among the catalysts examined, Raney cobalt

  已经开发了从相应的杂芳族酮获得杂芳族伯胺的方法。之前报道的将酮转化为伯胺的各种方法都在杂环酮上进行了研究，但没有成功，包括 Leuckart-Wallach 条件、硼烷还原和过渡金属催化的氢化。在所检测的催化剂中，阮内钴产生了所需的杂环伯胺。结构变化的杂环酮肟的阮内钴加氢在温和条件下以良好的选择性形成伯胺，并且产物易于以高产率分离。此外，这是对阮内钴作为肟加氢催化剂的能力进行系统评估的第一份报告。
• LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY, AND METHOD FOR PRODUCING LIQUID CRYSTAL DISPLAY
  申请人：JSR CORPORATION

  公开号：US20150092147A1

  公开（公告）日：2015-04-02

  A liquid crystal composition is described, including a liquid crystalline compound (A), and at least one nitrogen-containing compound (B) selected from compounds represented by formula (1) and compounds represented by formula (2), wherein R′ is a hydrogen atom or a monovalent organic group that is bonded to the nitrogen atom via a chain-shaped hydrocarbon group or an alicyclic hydrocarbon group, R 2 and R 3 are independently a divalent organic group that is bonded to the nitrogen atom via a chain-shaped hydrocarbon group, an alicyclic hydrocarbon group or *—CO—R 4 —, A 1 is a nitrogen-containing heteroaromatic ring, X 1 is a cyclic ether group or a polymerizable unsaturated group, and R 10 is a divalent organic group that is bonded to the primary amino group via a chain-shaped hydrocarbon group or an alicyclic hydrocarbon group.
• US5470855A
  申请人：——

  公开号：US5470855A

  公开（公告）日：1995-11-28
• US5780468A
  申请人：——

  公开号：US5780468A

  公开（公告）日：1998-07-14