(S)-1-(4-Aminophenyl)-2-pyrrolidinemethanol | 132041-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-1-(4-Aminophenyl)-2-pyrrolidinemethanol
• 英文别名: [(2S)-1-(4-aminophenyl)pyrrolidin-2-yl]methanol
• CAS: 132041-37-3
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: JKNODKXGKFKOCM-NSHDSACASA-N

物化性质

• 沸点：
  400.6±20.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(苯磺酰基)呋喃-2-甲醛 、 (S)-1-(4-Aminophenyl)-2-pyrrolidinemethanol 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到(S)-(-)-5-(phenylsulfonyl)-2-furaldehyde-4-[(2-hydroxymethyl)pyrrolidinyl]phenylimine
  参考文献：
  名称：

  手性脯氨醇取代发色团的合成及二阶非线性

  摘要：

  合成了一系列新的含噻吩和呋喃的发色团，具有手性脯氨醇供体和砜受体。描述了紫外-可见吸收、二阶非线性光学特性和 X 射线晶体结构。

  DOI：

  10.1002/jccs.200400072
• 作为产物：
  描述：

  1-溴-4-硝基苯 在 三乙胺 、 tin(ll) chloride 作用下， 以 甲苯 为溶剂， 反应 38.0h， 生成 (S)-1-(4-Aminophenyl)-2-pyrrolidinemethanol
  参考文献：
  名称：

  手性脯氨醇取代发色团的合成及二阶非线性

  摘要：

  合成了一系列新的含噻吩和呋喃的发色团，具有手性脯氨醇供体和砜受体。描述了紫外-可见吸收、二阶非线性光学特性和 X 射线晶体结构。

  DOI：

  10.1002/jccs.200400072

文献信息

• 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE
  申请人：Player R. Mark

  公开号：US20080114007A1

  公开（公告）日：2008-05-15

  The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R 101 and R 200 are described in the specification.

  本发明针对当前对选择性和强效蛋白酪氨酸激酶抑制剂的需求，提供对c-fms激酶的强效抑制剂。本发明涉及以下式I的新化合物： 或其盐、对映体、互变异构体、结晶、多晶型、无定形、溶剂化物、水合物、酯、前药或代谢物形式，其中A、Y、Z、R 101 和R 200 在说明书中有描述。
• Synthesis, structure and second-order nonlinear optical properties of highly functionalized 6-aminopentafulvenes
  作者：Joan F. Piniella、Angel Alvarez-larena、María A. Díaz-garcía、Fernando Agulló-lópez、Isabelle Ledoux、Joseph Zyss、Midori Kato、Masashi Kiguchi、M. Mar Miranda、Montserrat Muñoz、Elena Soler、Silvia Sorribes、Gabriel Germain

  DOI：10.1039/a707468i

  日期：——

  Novel donor–acceptor functionalized pentafulvenes have been synthesized and characterized. Structural data have been obtained by single crystal X-ray diffraction. Their molecular and macroscopic second-order nonlinear optical properties have been investigated,via electric field induced second harmonic generation (EFISH) in solution and by second harmonic generation with evanescent wave (SHEW) in the solid state.

  新颖的供体-受体功能化五富勒烯已被合成并表征出来。通过单晶 X 射线衍射获得了结构数据。研究人员通过溶液中的电场诱导二次谐波发生（EFISH）和固态中的蒸发波二次谐波发生（SHEW）研究了它们的分子和宏观二阶非线性光学特性。
• Silver nanoparticles stabilized by a polyaminocyclodextrin as catalysts for the reduction of nitroaromatic compounds
  作者：Marco Russo、Francesco Armetta、Serena Riela、Delia Chillura Martino、Paolo Lo Meo、Renato Noto

  DOI：10.1016/j.molcata.2015.07.031

  日期：2015.11

  Silver nanoparticles stabilized by means of poly-(6-N,N-dimethyl-propylenediamino)-(6-deoxy)-beta-cyclodextrin were synthesized, characterized by different techniques (UV-vis spectroscopy, Dynamic Light Scattering, High Resolution Transmission Electron Microscopy, Fourier-transform IR Spectroscopy) and used as catalysts for the reduction of various nitrobenzene derivatives with sodium borohydride. The nanocomposites obtained appear to have an organized structure, with a metal core surrounded by a layer-structured coating shell. Kinetic data, rationalized in terms of a modified Langmuir-Hinshelwood model, evidenced a non-linear dependence of the reaction rate on the concentration of the catalyst. This was explained on the grounds of the catalytic activity of differently covered catalyst areas. Careful analysis of kinetic data, in particular the effect of the para substituent on the nitroarene structure and the trends of the induction period observed at the beginning of the reaction, provided with interesting insights on the reaction course, and brought us to critically reconsider several mechanistic ideas reported in previous literature. (C) 2015 Elsevier B.V. All rights reserved.
• Oxidative hair dye compositions and methods containing 1-(4-aminophenyl)-2-pyrrolidinemethanols
  申请人：P&G-Clairol, Inc.

  公开号：EP0962452B1

  公开（公告）日：2003-09-17
• Synthesis and Second-Order Nonlinearities of Chiral Prolinol-Substituted Chromophores
  作者：Shang-Shing P. Chou、Chiung-Yi Yu、Hong-Cheu Lin、Pao-Keng Yang

  DOI：10.1002/jccs.200400072

  日期：2004.6

  A new series of thiophene- and furan-containing chromophores with a chiral prolinol donor and a sulfone acceptor has been synthesized. The UV-vis absorptions, second-order nonlinear optical properties, and X-ray crystal structures are described.

  合成了一系列新的含噻吩和呋喃的发色团，具有手性脯氨醇供体和砜受体。描述了紫外-可见吸收、二阶非线性光学特性和 X 射线晶体结构。