2-(4-(4-chloro-3-fluorophenyl)thiazol-2-yl)-1-(3-phenylisoquinolin-1-yl)hydrazine | 1214257-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-(4-chloro-3-fluorophenyl)thiazol-2-yl)-1-(3-phenylisoquinolin-1-yl)hydrazine
• 英文别名: 1-[4-(4-Chloro-3-fluorophenyl)-1,3-thiazol-2-yl]-2-(3-phenylisoquinolin-1-yl)hydrazine
• CAS: 1214257-80-3
• 化学式: C₂₄H₁₆ClFN₄S
• 分子量: 446.935
• InChiKey: QVRRHAQTCAMZOP-UHFFFAOYSA-N

物化性质

• 熔点：
  146 °C(Solvent: Chloroform)
• 沸点：
  638.3±65.0 °C(predicted)
• 密度：
  1.427±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  Α-溴代-3-氟-4-氯苯乙酮 、 氨基硫脲 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到2-(4-(4-chloro-3-fluorophenyl)thiazol-2-yl)-1-(3-phenylisoquinolin-1-yl)hydrazine
  参考文献：
  名称：

  Synthesis of Some New 2,4-Disubstituted Hydrazinothiazoles and 2,5-Disubstituted Thiazolidinones

  摘要：

  A series of hydrazinothiazoles has been synthesized by the condensation of thiosemicarbazones and alpha-bromoketones. Similarly the hydrazinothiazolidiones were prepared by the condensation of thiosemicarbazone and alpha-bromoesters. The newly synthesized compounds were characterized by NMR and LCMS studies.

  DOI：

  10.1080/10426500802625404

文献信息

• Synthesis of Some New 2,4-Disubstituted Hydrazinothiazoles and 2,5-Disubstituted Thiazolidinones
  作者：P. Manivel、F. Nawaz Khan

  DOI：10.1080/10426500802625404

  日期：2009.10.30

  A series of hydrazinothiazoles has been synthesized by the condensation of thiosemicarbazones and alpha-bromoketones. Similarly the hydrazinothiazolidiones were prepared by the condensation of thiosemicarbazone and alpha-bromoesters. The newly synthesized compounds were characterized by NMR and LCMS studies.