N,N'-disalicylidene-1,3-diamino-2-hydroxypropane | 133345-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-disalicylidene-1,3-diamino-2-hydroxypropane
• 英文别名: N,N'-(propan-2-ol)bis(salicylaldimine)；1,3-bis(salicylideneamino)-2-propanol；1,3-bis(salicylideneamino)propan-2-ol；1,3-bis(salycilideneamino)-2-propanol
• CAS: 133345-52-5
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: STCBWDOQWRPRIX-VNIJRHKQSA-N

物化性质

• 沸点：
  501.1±50.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  85.41
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N,N'-disalicylidene-1,3-diamino-2-hydroxypropane 、 乙二胺 以 甲醇 为溶剂， 生成 Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis-, (E,E)-
  参考文献：
  名称：

  铀酰稳定的席夫碱复合物。

  摘要：

  在过量乙二胺（EDA）存在下的Uranyl Schiff碱络合物[（UO（2））（2）（Salpro）（OH）（溶剂）（2）]（1）不经历亲核加成（水解）和取代弹性骨架延长螯合[2N，3O + OH]引起的（氨基转移）反应。

  DOI：

  10.1039/b712322a
• 作为产物：
  描述：

  邻甲基苄醇 、 1,3-二氨基-2-羟基丙烷 以 甲醇 为溶剂， 生成 N,N'-disalicylidene-1,3-diamino-2-hydroxypropane
  参考文献：
  名称：

  Spectrofluorimetric determination of trace aluminum in diluted hemodialysis solutions

  摘要：

  In this study, a spectrofluorimetric method has been developed for the determination of aluminum based on the formation of an aluminum complex with N,N'-disalicylidene-1,3-diamino-2-hydroxypropane (DSAHP). The most suitable pH, solvent medium, complex formation time, Schiff base concentration and temperature were determined. The excitation and emission wavelengths were 270 and 437 nm, respectively, in which the DSAHP-Al complex gave the maximum flurescence intensity at pH 3.0 and 6.0 in 50% dioxan-50% water medium. Under these conditions, calibration curves were obtained in three different linear limits, and was found that aluminum could be detected within the concentration limit of 0-10.0 muM and the lowest detection limit being 0.27 ng ml(-1). The stochiometry of the DSAHP-Al complex was also determined spectrofluorimetrically under optimal conditions and the molar ratio of DSAHP-Al was calculated as 2 :1. Using the developed method, aluminum was detected in hemodialysis solutions, and the results obtained were similar and comparable with those obtained using the method described in the British Pharmacopoeia within 95% confidence limits. This method can be used successfully for the routine determination of aluminum because it is quick, requires less amount of reactives, is sensitive, reliable and reproducible. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2004.05.039

文献信息

• [EN] TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2<br/>[FR] DÉRIVÉS DE TÉTRAHYDROISOQUINOLÉINE UTILES EN TANT QU'INHIBITEURS DE DIACYLGLYCÉRIDE O-ACYLTRANSFÉRASE 2
  申请人：MERCK SHARP & DOHME

  公开号：WO2016036636A1

  公开（公告）日：2016-03-10

  The present invention relates to a compound represented by formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ("DGAT2") and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

  本发明涉及一种由式I表示的化合物及其药学上可接受的盐。式I的化合物是二酰甘油O-酰基转移酶2（“DGAT2”）的抑制剂，可能在治疗、预防和抑制由DGAT2介导的疾病中有用。本发明的化合物可能在治疗肝脂肪变性、糖尿病、肥胖、高脂血症、高胆固醇血症、动脉粥样硬化、心脏肾脏疾病（如慢性肾脏疾病和心力衰竭）以及相关疾病和病况中有用。
• Hydroxy- and alkoxy-bridged dinuclear uranyl–Schiff base complexes: hydrolysis, transamination and extraction studies
  作者：Mohan S. Bharara、Kathryn Heflin、Stephen Tonks、Kara L. Strawbridge、Anne E. V. Gorden

  DOI：10.1039/b800469b

  日期：——

  conformations. Under similar reaction conditions, using ethylenediamine as a base, the respective Salen-based uranyl compounds, [UO2(Salen)(MeOH)] (3) and [UO2(But2-Salen)(MeOH)] (4) are obtained due to transamination of the ligand backbone. Complexes 1·(MeOH)2 and 2·(MeOH)2 when reacted with an excess of ethylenediamine failed to yield the respective Salen-based complexes, 3 and 4, respectively. The new compounds

  硝酸铀酰与 1,3-双（水杨亚氨基）-2-丙醇（H 3 L1）和1,3-双（3,5-二叔丁基水杨亚氨基）-2-丙醇（H 3 L2）存在三乙胺（Et 3 N）产生羟基和烷氧基桥连的双核配合物。[（UO 2）2（L1）（OH）（MeOH）2 ]·（MeOH）2（1 ·（MeOH）2）和[（UO 2）2（L2）（OH）（MeOH）2 ]·（ MeOH）2（2 ·（MeOH）2）。1 ·（DMF）2和2 ·（DMF）2的晶体结构表现出不对称的中心U 2 O 2核心，该核心涉及桥接烷氧基和羟基氧原子。铀中心周围的几何形状1 ·（DMF）2和2 ·（DMF）2是扭曲的五边形双锥体，其溶剂分子占据第五个协调位点。与1 ·（DMF）2相比，配体主链的柔性性质在2 ·（DMF）2中更为明显，每单位细胞产生两个分子的构象不同。在相似的反应条件下，使用乙二胺作为碱，由于对氨基苯甲酸酯的转氨作用，获得了相应的Salen基铀酰化合物[UO
• Novel bifunctional chelating compounds containing hydroxamic acid residues
  申请人：Draximage, Inc.

  公开号：EP2266953A1

  公开（公告）日：2010-12-29

  New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presence of a linker moiety in the molecular structure of these chelators.

  本研究提供了新型羟肟酸基双功能螯合剂。这些螯合剂设计用于螯合可通过顺磁性或放射性特性进行检测的金属离子。通过在这些螯合剂的分子结构中加入连接分子，可实现与肽或蛋白质的共轭。
• Tridentate coordination of dioxomolybdenum(VI) with some potentially quinquedentate (N2O3) Schiff base ligands
  作者：James H. Cameron、John A. McEwan

  DOI：10.1016/s0020-1693(00)82851-0

  日期：1993.9

  Three complexes of molybdenum(VI) 4-6 have been prepared and characterised using potentially quinquedentate ligands derived from Schiff base condensations using 1,3-diamino-2-hydroxypropane. From NMR spectroscopic evidence it is clear that the ligands bind to the metal ion in a terdentate manner, leaving two of the possible ligand donor atoms uncoordinated. This represents a new coordination mode for monomeric complexes of these ligands with a transition metal ion. In solution, the sixth coordination site of the MoO22+ ion is occupied by a solvent molecule while in the solid state, the C-13 NMR spectrum of 4 suggests that the sixth coordination site of MoO22+ is occupied by a phenolic oxygen, probably via an intermolecular interaction between the complexes.
• A doubly bridged binuclear iron(III) complex containing inequivalent metal environments. Synthesis, structure and magnetism
  作者：Gary D. Fallon、Andrew Markiewicz、Keith S. Murray、Thao Quach

  DOI：10.1039/c39910000198

  日期：——

  New doubly bridged iron(III) complexes [Fe2(LA)(OMe)(Cl)2MeOH]1 and [Fe2(LB)(OH)Cl2]2, have been synthesized using the binucleating ligands H3LA=N, N′-bissalicylidene-1,3-diaminopropan-2-ol; and H3LB=N, N′-bissalicylideneimine-1,5-diaminopentan-3-ol; the crystal structure of 1 shows inequivalent coordination environments, a feature which is relevant to Fe geometries in iron-oxo proteins, and 1 shows an intramolecular antiferromagnetic J value of –10.6 cm–1.