methyl 3-{3-[(2,5-dimethylphenyl)thio]-5-isopropyl-1H-indol-2-yl}-2,2-dimethylpropanoate | 854279-83-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: methyl 3-{3-[(2,5-dimethylphenyl)thio]-5-isopropyl-1H-indol-2-yl}-2,2-dimethylpropanoate
• 英文别名: methyl 3-[3-(2,5-dimethylphenyl)sulfanyl-5-propan-2-yl-1H-indol-2-yl]-2,2-dimethylpropanoate
• CAS: 854279-83-7
• 化学式: C₂₅H₃₁NO₂S
• 分子量: 409.593
• InChiKey: KLVLSUCXJBXODY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 5-[(2,5-dimethylphenyl)thio]-2,2-dimethyl-4-oxopentanoate 、 4-异丙基苯肼盐酸盐 以 叔丁醇 为溶剂， 反应 3.0h， 以37%的产率得到methyl 3-{3-[(2,5-dimethylphenyl)thio]-5-isopropyl-1H-indol-2-yl}-2,2-dimethylpropanoate
  参考文献：
  名称：

  [EN] 1-ALKYL-3-THIO-SUBSTITUTED INDOLE-2-ALKYNOIC ACIDS USEFUL FOR THE TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS
  [FR] ACIDES INDOLE-2-ALKYNOIQUES 1-ALKYL-3-THIO-SUBSTITUES UTILISES DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER ET LES ETATS ASSOCIES

  摘要：

  式(I)的化合物：调节Υ-分泌酶的活性，因此可用于治疗或预防阿尔茨海默病及相关疾病。

  公开号：

  WO2005054193A1

文献信息

• 1-Alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment of alzheimer's disease and related conditions
  申请人：Beher Dirk

  公开号：US20070142453A1

  公开（公告）日：2007-06-21

  Compounds of formula I: modulate the activity of γ-secretase, and hence find use in treatment or prevention of Alzheimer's disease and related conditions.

  化合物I的公式：调节γ-分泌酶的活性，因此可用于治疗或预防阿尔茨海默病及相关疾病。
• Use of amines and/or mannich adducts in fuel and lubricant compositions for direct injection spark ignition engines
  申请人：Lange Arno

  公开号：US20060070293A1

  公开（公告）日：2006-04-06

  The present invention relates to the use of amines and/or Mannich adducts as detergents and/or dispersants in fuel and lubricant compositions for direct-injection gasoline engines. The invention further relates to fuel and lubricant compositions which comprise at least one such Mannich adduct, and also a bisaminoalkylated Mannich adduct.

  本发明涉及胺和/或曼尼希加合物作为清洁剂和/或分散剂在直喷式汽油发动机的燃料和润滑油组合物中的用途。本发明还涉及包含至少一种此类曼尼希加合物以及一种双氨基烷基化曼尼希加合物的燃料和润滑剂组合物。
• 1-ALKYL-3-THIO-SUBSTITUTED INDOLE-2-ALKYNOIC ACIDS USEFUL FOR THE TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS
  申请人：Merck and Co., Inc.

  公开号：EP1708997B1

  公开（公告）日：2009-10-21
• USE OF AMINES AND/OR MANNICH ADDUCTS IN FUEL AND LUBRICANT COMPOSITIONS FOR DIRECT INJECTION SPARK IGNITION ENGINES
  申请人：BASF SE

  公开号：US20130237466A1

  公开（公告）日：2013-09-12

  The present invention relates to the use of amines and/or Mannich adducts as detergents and/or dispersants in fuel and lubricant compositions for direct-injection gasoline engines. The invention further relates to fuel and lubricant compositions which comprise at least one such Mannich adduct, and also a bisaminoalkylated Mannich adduct.
• USE OF AMINES AND/OR MANNICH ADDUCTS IN FUEL AND LUBRICANT COMPOSITIONS FOR DIRECT-INJECTION SPARK IGNITION ENGINES
  申请人：BASF SE

  公开号：US20160222309A1

  公开（公告）日：2016-08-04

  The present invention relates to the use of amines and/or Mannich adducts as detergents and/or dispersants in fuel and lubricant compositions for direct-injection gasoline engines. The invention further relates to fuel and lubricant compositions which comprise at least one such Mannich adduct, and also a bisaminoalkylated Mannich adduct.