bis-t-butylaminodiethylene glycol | 114824-96-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-t-butylaminodiethylene glycol
• 英文别名: 2,2'-tertiary-butylamino ethyl ether；2,2'-tertiary-butylaminoethyl ether；N-[2-[2-(tert-butylamino)ethoxy]ethyl]-2-methylpropan-2-amine
• CAS: 114824-96-3
• 化学式: C₁₂H₂₈N₂O
• 分子量: 216.367
• InChiKey: ZAWCVKBSJMRLLG-UHFFFAOYSA-N

物化性质

• 沸点：
  267.2±15.0 °C(Predicted)
• 密度：
  0.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  叔丁胺 、 二乙二醇 在 Ni-5132P nickel catalyst 氢气 作用下， 200.0 ℃ 、2.76 MPa 条件下， 反应 4.0h， 生成 叔丁胺基乙氧基乙醇 、 bis-t-butylaminodiethylene glycol 、 4-叔丁基吗啉
  参考文献：
  名称：

  Improved Synthesis of Severely Sterically Hindered Amino-Ether Alcohols and Diaminopolyalkenyl Ethers Using a High Activity Powder Catalyst

  摘要：

  本发明涉及一种制备严重立体位阻的二次胺醚醇和二胺聚烯基醚的方法，通过在高活性镍粉加氢催化剂存在下，将一种初级氨基化合物与聚烯基醚乙二醇反应，以实现对反应物的高转化率和对期望最终产物的增加选择性。

  公开号：

  US20080058553A1

文献信息

• DENDRITIC COMPOUNDS INCLUDING A CHELATING, FLUOROCHROME OR RECOGNITION AGENT, COMPOSITIONS INCLUDING SAME AND USES THEREOF
  申请人：UNIVERSITE DE STRASBOURG

  公开号：US20160221992A1

  公开（公告）日：2016-08-04

  The invention relates to dendritic compounds comprising a chelating, fluorochrome or recognition agent of formula (I), to compositions comprising same, and to uses thereof, wherein in said formula (I): T, L1, D, R, L2, V and n are as defined in the description.

  这项发明涉及包含式(I)的螯合、荧光染料或识别剂的树突化合物，以及包含这些化合物的组合物和它们的用途，其中在所述的式(I)中：T、L1、D、R、L2、V和n如描述中所定义。
• CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
  申请人：Arvinas, Inc.

  公开号：US20180215731A1

  公开（公告）日：2018-08-02

  The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及cereblon E3连接酶结合化合物，包括包含相同成分的双功能化合物，这些化合物作为靶向泛素化的调节剂具有实用价值，尤其是抑制剂，可降解和/或以其他方式抑制根据本公开的双功能化合物。特别是，该描述提供了化合物，其一端含有与cereblon E3泛素连接酶结合的配体，另一端含有与目标蛋白结合的部分，使目标蛋白位于泛素连接酶附近以降解（和抑制）该蛋白。可以合成表现出广泛药理活性的化合物，与几乎所有类型的靶向多肽的降解/抑制一致。
• [EN] CATALYTIC PREPARATION OF SEVERELY STERICALLY HINDERED AMINO-ETHER ALCOHOLS USING A METAL LOADED CATALYST<br/>[FR] PREPARATION CATALYTIQUE D'ALCOOLS AMINO-ETHER A ENCOMBREMENT STERIQUE SEVERE UTILISANT UN CATALYSEUR A CHARGE METALLIQUE
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2005082834A1

  公开（公告）日：2005-09-09

  The present invention relates to a process for the production of severely sterically hindered amino-ether alcohols using a catalyst based on the combination of one or more catalytically active metals supported in a dispersed form on one or more ordered mesoporous materials as support.

  本发明涉及一种利用基于一个或多个催化活性金属的组合在一个或多个有序介孔材料上以分散形式支撑的催化剂的过程，用于生产严重立体位阻的氨基醚醇。
• MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20170008904A1

  公开（公告）日：2017-01-12

  The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  描述涉及MDM2结合化合物，包括包含相同结构的双功能化合物，这些化合物可作为靶向泛素化的调节剂，特别是根据本发明抑制各种多肽和其他蛋白质的化合物。具体而言，描述提供了一种化合物，其一端含有结合到MDM2 E3泛素连接酶的配体，另一端含有结合到靶蛋白的基团，使得靶蛋白与泛素连接酶靠近，以促使该蛋白的降解（和抑制）。可以合成出一系列具有广泛药理活性的化合物，与几乎任何类型的靶向多肽的降解/抑制一致。
• [EN] PROCESS FOR REMOVAL OF ACID GASES FROM A FLUID STREAM<br/>[FR] PROCÉDÉ D'ÉLIMINATION DE GAZ ACIDES CONTENUS DANS UN COURANT DE FLUIDE
  申请人：BASF SE

  公开号：WO2021047928A1

  公开（公告）日：2021-03-18

  A process for removing acid gases from a fluid stream, wherein the fluid stream is contacted with an absorbent to obtain a treated fluid stream and a laden absorbent, the absorbent comprising at least one diluent and a compound of the general formula (I) wherein R1 is C1-C3-alkyl; R2 is C1-C3-alkyl; R3 is selected from hydrogen and C1-C3-alkyl; R4 is selected from hydrogen and C1-C3-alkyl and n is an integer in the range of 1 to 4.

  一种从流体流中去除酸性气体的方法，其中将流体流与吸收剂接触以获得处理后的流体流和负载吸收剂，所述吸收剂包括至少一种稀释剂和一种具有通式（I）的化合物，其中R1为C1-C3烷基；R2为C1-C3烷基；R3选自氢和C1-C3烷基；R4选自氢和C1-C3烷基，n为1至4的整数。