Allenes bearing a nucleophilic group cyclize on treatment with acyltetracarbonyl cobalt complexes in the presence of mild bases. Various nucleophilic groups and cobalt complexes can be used to give highly functionalized pyrrolidines, cyclopentanes and tetrahydrofurans. Disubstituted allenes may be used in the reaction. 1,3-disubstituted allenes give products with high stereoselectivity.
Acylation-cyclization of allenes using acyltetracarbonylcobalt complexes
作者:Roderick W. Bates、Thota Rama Devi
DOI:10.1016/0040-4039(94)02297-o
日期:1995.1
Allenes bearing tethered nucleophiles undergo acylation-cyclization on treatment with acylcobalt complexes and base.
Reactions of Iminium Ions with Michael Acceptors through a Morita–Baylis–Hillman-Type Reaction: Enantiocontrol and Applications in Synthesis
作者:Eddie L. Myers、Johannes G. de Vries、Varinder K. Aggarwal
DOI:10.1002/anie.200604715
日期:2007.3.5
Diastereoselectivity in Michael Additions to a Pyrrolidinyl Enone