3,3-Dimethyl-4-(pyridin-2-yl)butan-2-one | 88356-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,3-Dimethyl-4-(pyridin-2-yl)butan-2-one
• 英文别名: 3,3-dimethyl-4-pyridin-2-ylbutan-2-one
• CAS: 88356-07-4
• 化学式: C₁₁H₁₅NO
• 分子量: 177.24
• InChiKey: LODAKJCDOZQXOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative,and inflammatory disorders
  申请人：Graziani Idris Edmund

  公开号：US20060135549A1

  公开（公告）日：2006-06-22

  The present invention provides compounds of the following structure, wherein R 1 , R 2 , R 4 , R 4′ , R 6 , R 7 , and R 15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.

  本发明提供以下结构的化合物，其中R1、R2、R4、R4'、R6、R7和R15如上所定义：这些化合物可用于治疗神经系统疾病或中风或头部受伤引起的并发症；良性或恶性肿瘤性疾病、癌瘤和腺癌；增生性疾病；以及炎症性疾病。因此，这些化合物可用作神经保护和神经再生、抗增殖和抗炎药物。
• A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND
  申请人：PTT Global Chemical Public Company Limited

  公开号：EP3405453A2

  公开（公告）日：2018-11-28
• Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
  申请人：Graziani Idris Edmund

  公开号：US20070142423A1

  公开（公告）日：2007-06-21

  The present invention provides compounds of the following structure, wherein R 1 , R 2 , R 4 , R 4′ , R 6 , R 7 , and R 15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.
• Rapamycin analogues and the uses thereof in the treatment of neurological disorders
  申请人：Graziani Idris Edmund

  公开号：US20080004264A1

  公开（公告）日：2008-01-03

  Compounds of the following structure, wherein R 1 , R 2 , R 4 , R 4′ , R 6 , R 7 , and R 15 are defined above, are provided: These compounds are useful in treating neurological disorders or complications due to stroke or head injury. The compounds are therefore useful as neuroprotective and neuroregenerative agents.
• Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
  申请人：Graziani Idris Edmund

  公开号：US20080027089A1

  公开（公告）日：2008-01-31

  Pharmaceutical composition containing compounds of the following structure, wherein R 1 -R 9 , R 15 , and n are defined herein, are provided. These compositions are useful in treating neurological disorders or complications due to stroke or head injury, and as neuroprotective and neuroregenerative agents.