2,6-dimethyl-4'-chloro-1,1'-biphenyl | 724423-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dimethyl-4'-chloro-1,1'-biphenyl
• 英文别名: 2,6-dimethyl-4'-chlorobiphenyl；1,1'-Biphenyl, 4'-chloro-2,6-dimethyl-；2-(4-chlorophenyl)-1,3-dimethylbenzene
• CAS: 724423-52-3
• 化学式: C₁₄H₁₃Cl
• 分子量: 216.71
• InChiKey: HMSKQKDJYMYTKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,6-二甲基溴苯 、 4-氯苯硼酸 在 potassium phosphate 、 四丁基溴化铵 作用下， 以 水 为溶剂， 反应 2.5h， 以85%的产率得到2,6-dimethyl-4'-chloro-1,1'-biphenyl
  参考文献：
  名称：

  Palladium acetate immobilized in a hierarchical MFI zeolite-supported ionic liquid: a highly active and recyclable catalyst for Suzuki reaction in water

  摘要：

  钯醋酸盐被固定在层状离子液体薄层上，涂覆于层次化MFI沸石的介孔壁上，并作为催化剂在水相中测试了铃木耦合反应。该催化剂在多种芳基溴化物与芳基硼酸的耦合反应中表现出非常高的活性。此外，该催化剂能够循环使用，几乎没有显著的催化活性损失。

  DOI：

  10.1039/b817855k

文献信息

• A new precatalyst for the Suzuki reaction—a pyridyl-bridged dinuclear palladium complex as a source of mono-ligated palladium(<scp>0</scp>)
  作者：Andrew Beeby、Sylvia Bettington、Ian J. S. Fairlamb、Andrés E. Goeta、Anant R. Kapdi、Elina H. Niemelä、Amber L. Thompson

  DOI：10.1039/b401077a

  日期：——

  pyridyl-bridged palladium complex, trans-(P,N)-[PdBr(μ-C5H4N-C2,N)(PPh3)]21, was obtained from material isolated from the Suzuki cross-coupling reaction of 2-bromopyridine with 2,4-difluorophenylboronic acid in the presence of catalytic (PPh3)4Pd. Complex 1 is an effective precatalyst for the Suzuki cross-coupling reactions of a variety organoboronic acids and aryl bromides, and represents a useful source of mono-ligated

  双核 吡啶基-bridged钯络合物，反式- （P，Ñ） - [PDBR（μ -C 5 ħ 4 N-C 2，N）（PPH 3）] 2 1，从材料获得从的Suzuki交叉偶联反应中分离2-溴吡啶 和 2,4-二氟苯基硼酸在催化（PPh 3）4 Pd的存在下。配合物1是多种有机硼酸和芳基溴化物的Suzuki交叉偶联反应的有效前催化剂，并且代表单连接钯（0）“（Ph 3 P）Pd（0）”的有用来源。
• Bis(triphenylphosphine)palladium(II)succinimide as a precatalyst for Suzuki cross-coupling—subtle effects exerted by the succinimide ligand
  作者：Ian J.S. Fairlamb、Anant R. Kapdi、Jason M. Lynam、Richard J.K. Taylor、Adrian C. Whitwood

  DOI：10.1016/j.tet.2004.05.018

  日期：2004.6

  A new palladium(II) precatalyst for Suzuki cross-coupling of aryl halides and organoboronic acids has been identified, namely bis(triphenylphosphine)palladium(II)succinimide [(Ph3P)(2)Pd(N-Succ)(2)] 2. The precatalyst is easily prepared from palladium(O) precursors, such as (Ph3P)(4)Pd or Pd(2)dba(3). CHCl3/Ph3P and succinimide, is air, light and moisture stable, and may be employed with a variety of substrates to give the cross-coupled products, in good yields and in reasonable time, at relatively low catalyst loadings. (C) 2004 Elsevier Ltd. All rights reserved.
• Palladium acetate immobilized in a hierarchical MFI zeolite-supported ionic liquid: a highly active and recyclable catalyst for Suzuki reaction in water
  作者：Myung-Jong Jin、Abu Taher、Hee-Jae Kang、Minkee Choi、Ryong Ryoo

  DOI：10.1039/b817855k

  日期：——

  Palladium acetate was immobilized in thin ionic liquid layers on the mesopore wall of hierarchical MFI zeolite, and tested as a catalyst for Suzuki coupling reaction in water. The catalyst exhibited very high activity in the coupling of various aryl bromides with arylboronic acids. Moreover, the catalyst could be recycled without a significant loss of catalytic activity.

  钯醋酸盐被固定在层状离子液体薄层上，涂覆于层次化MFI沸石的介孔壁上，并作为催化剂在水相中测试了铃木耦合反应。该催化剂在多种芳基溴化物与芳基硼酸的耦合反应中表现出非常高的活性。此外，该催化剂能够循环使用，几乎没有显著的催化活性损失。