2-(2-(phenylethynyl)phenyl)benzofuran | 1123867-46-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(2-(phenylethynyl)phenyl)benzofuran
• 英文别名: 2-(2-(2-phenylethynyl)phenyl)-benzofuran；2-[2-(2-Phenylethynyl)phenyl]-1-benzofuran；2-[2-(2-phenylethynyl)phenyl]-1-benzofuran
• CAS: 1123867-46-8
• 化学式: C₂₂H₁₄O
• 分子量: 294.353
• InChiKey: RSEXCRVDIPFLFD-UHFFFAOYSA-N

物化性质

• 沸点：
  479.0±28.0 °C(predicted)
• 密度：
  1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-(phenylethynyl)phenyl)benzofuran 在 三苯基膦氯金 、 silver trifluoromethanesulfonate 作用下， 以 邻二甲苯 为溶剂， 反应 8.33h， 以96%的产率得到6-phenylnaphtho[1,2-b]benzofuran
  参考文献：
  名称：

  Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes

  摘要：

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.

  DOI：

  10.1021/ol302922t
• 作为产物：
  描述：

  2-碘苯酚 、 1-乙炔基-2-(2-苯基乙炔基)苯 在 bis-triphenylphosphine-palladium(II) chloride 、 三乙胺 、 三苯基膦氯金 、 silver trifluoromethanesulfonate 作用下， 以 邻二甲苯 为溶剂， 反应 1.33h， 以65%的产率得到2-(2-(phenylethynyl)phenyl)benzofuran
  参考文献：
  名称：

  Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes

  摘要：

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.

  DOI：

  10.1021/ol302922t

文献信息

• Halopalladation/Decarboxylation/Carbon−Carbon Forming Domino Process: Synthesis of 5-Halo-6-substituted Benzo[<i>b</i>]naphtho[2,1-<i>d</i>]furans
  作者：Xiao-Cheng Huang、Feng Wang、Yun Liang、Jin-Heng Li

  DOI：10.1021/ol8029752

  日期：2009.3.5

  A novel and general holopalladation/decarboxylation/carbon - carbon forming domino protocol is described for the synthesis of 5-halo-6-substituted benzo[b]naphtho[2,1-d]furans. The protocol represents the first example of trapping the sigma-vinylpalladium intermediate, generated from halopalladation of alkynes, by the decarboxylative coupling reaction.
• Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes
  作者：Philip M. Byers、Julian I. Rashid、Rana K. Mohamed、Igor V. Alabugin

  DOI：10.1021/ol302922t

  日期：2012.12.7

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.