methyl 2-(benzo[d][1,3]dioxol-6-yl)-2,3-diphenylpropanoate | 1334531-88-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: methyl 2-(benzo[d][1,3]dioxol-6-yl)-2,3-diphenylpropanoate
• 英文别名: Methyl 2-(1,3-benzodioxol-5-yl)-2,3-diphenylpropanoate；methyl 2-(1,3-benzodioxol-5-yl)-2,3-diphenylpropanoate
• CAS: 1334531-88-2
• 化学式: C₂₃H₂₀O₄
• 分子量: 360.409
• InChiKey: AHCPUPYYSFFTAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯并[1,3]二氧代l-5-乙酸甲酯 在 [Rh(OH)(cod)]2 、 4-乙酰氨基苯磺酰叠氮 、 potassium tert-butylate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲基叔丁基醚 、 乙腈 为溶剂， 反应 4.0h， 生成 methyl 2-(benzo[d][1,3]dioxol-6-yl)-2,3-diphenylpropanoate
  参考文献：
  名称：

  Rhodium-Catalyzed Cross-Coupling Reaction of Arylboronates and Diazoesters and Tandem Alkylation Reaction for the Synthesis of Quaternary α,α-Heterodiaryl Carboxylic Esters

  摘要：

  A rhodium-catalyzed one-pot three-component coupling reaction was developed for the synthesis of quaternary alpha,alpha-heterodiaryl carboxylic esters. This reaction involves cross-coupling of the arylrhodium(I) complexes with alpha-aryldiazoacetates to form oxa-pi-allylrhodium complexes. With KOfBu and alkyl halides, tandem alkylation of the allyl complex occurs to form a quaternary stereocenter at the carbenic carbon.

  DOI：

  10.1021/ol2022577

文献信息

• Rhodium-Catalyzed Cross-Coupling Reaction of Arylboronates and Diazoesters and Tandem Alkylation Reaction for the Synthesis of Quaternary α,α-Heterodiaryl Carboxylic Esters
  作者：Yuk-Tai Tsoi、Zhongyuan Zhou、Wing-Yiu Yu

  DOI：10.1021/ol2022577

  日期：2011.10.7

  A rhodium-catalyzed one-pot three-component coupling reaction was developed for the synthesis of quaternary alpha,alpha-heterodiaryl carboxylic esters. This reaction involves cross-coupling of the arylrhodium(I) complexes with alpha-aryldiazoacetates to form oxa-pi-allylrhodium complexes. With KOfBu and alkyl halides, tandem alkylation of the allyl complex occurs to form a quaternary stereocenter at the carbenic carbon.