2-甲基-1H-咪唑并[4,5-b]吡嗪 | 38956-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 中文名称: 2-甲基-1H-咪唑并[4,5-b]吡嗪
• 英文名称: 2-methyl-1H-imidazo[4,5-b]pyrazine
• 英文别名: 2-methyl-1H-imidazo[4,5-b]pyrazine；2-Methyl-1H-imidazo[4,5-b]pyrazin；2-Methyl-1H-imidazo<4,5-b>pyrazin
• CAS: 38956-46-6
• 化学式: C₆H₆N₄
• mdl: MFCD08669464
• 分子量: 134.14
• InChiKey: JIHDDMXKBQBWHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-甲基-1H-咪唑并[4,5-b]吡嗪 、 氯 以61%的产率得到
  参考文献：
  名称：

  TONG Y. C., J. HETEROCYCL. CHEM. , 1975, 12, NO 6, 1127-1131

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二氨基哌嗪 、 乙酸酐 生成 2-甲基-1H-咪唑并[4,5-b]吡嗪
  参考文献：
  名称：

  Metabolite Analogs. V. Preparation of Some Substituted Pyrazines and Imidazo [b]pyrazines

  摘要：

  DOI：

  10.1021/ja01582a066

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• [EN] HINDERED DISULFIDE DRUG CONJUGATES<br/>[FR] CONJUGUÉS MÉDICAMENTEUX À PONT DISULFURE ENCOMBRÉ
  申请人：GENENTECH INC

  公开号：WO2017064675A1

  公开（公告）日：2017-04-20

  The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.

  该发明一般涉及二硫键药物偶联物，其中含有至少一个被至少一个碳氢化合物或取代碳氢化合物所取代的含硫碳原子的连接剂通过二硫键与靶向载体的半胱氨酸硫原子偶联，并且连接剂进一步与药物部分偶联。该发明进一步涉及适合通过二硫键与靶向载体偶联的活化连接剂-药物偶联物。该发明还进一步涉及制备受阻二硫键药物偶联物的方法。
• 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY
  申请人：Berge John

  公开号：US20070213362A1

  公开（公告）日：2007-09-13

  A method of inhibiting MetRS activity comprises administering to a patient in need thereof a MetRS inhibiting effective amount of a compound of the formula (I). A method of treating a resistant or multiply-resistant E. faecalis infection, a resistant or multiply-resistant S. aureus infection, and/or a resistant or multiply-resistant S. epidermidis infection comprises administering to a patient in need thereof an antibacterially effective amount of a compound of the formula (I).

  一种抑制MetRS活性的方法包括向需要治疗的患者投予化合物(I)的抑制剂有效量。一种治疗耐药或多重耐药E. faecalis感染，耐药或多重耐药S. aureus感染和/或耐药或多重耐药S. epidermidisinfection的方法包括向需要治疗的患者投予化合物(I)的抗菌有效量。
• Polymerisation Catalyst
  申请人：Gibson Vernon Charles

  公开号：US20080200625A1

  公开（公告）日：2008-08-21

  A polymerisation catalyst comprising (1) a transition metal compound of Formula (A), and optionally (2) an activator, wherein Z is 5-membered heterocyclic containing carbon, nitrogen and at least one other selected from nitrogen, sulphur and oxygen, the remaining atoms in the ring being nitrogen and carbon; M is a metal from Group 3 to 11 or a lanthanide metal; E 1 and E 2 are divalent hydrocarbon, heterocyclic or heterosubstituted derivatives of these; D 1 and D 2 are donor atoms or groups; X is an anionic group, L is a neutral donor group; n=m=zero or 1; y and z are zero or integers so that X and L satisfy the valency/oxidation state of M, characterized in that the complex contains at least one polymerisable olefinic double bond which is present in, or substituent to, at least one of the atoms, groups or ligands represented by Z, E, D and L. The catalyst binds to the forming polymer providing product with good particle morphology.

  一种聚合催化剂，包括（1）式（A）的过渡金属化合物，以及可选的（2）活化剂，其中Z是含有碳、氮和至少一种从氮、硫和氧中选择的其他元素的5元杂环，环中其余原子为氮和碳；M是3到11组或镧系金属中的金属；E1和E2是二价的碳氢化合物、杂环或这些的杂基衍生物；D1和D2是给体原子或基团；X是负离子基团，L是中性给体基团；n=m=0或1；y和z为零或整数，以使X和L满足M的化合价/氧化态，其特征在于该配合物至少含有一个聚合性烯烃双键，该双键存在于Z、E、D和L所代表的原子、基团或配体中的至少一个中或代替其中之一。催化剂与形成的聚合物结合，提供具有良好颗粒形态的产品。
• Diene Polymerisation
  申请人：Jacobsen Grant Berent

  公开号：US20100022724A1

  公开（公告）日：2010-01-28

  A process for producing homopolymers or copolymers of conjugated dienes comprising contacting monomeric material comprising at least one conjugated diene with a catalyst system comprising two or more different transition metal compounds and optionally one or more activators. Preferred transition metal compounds are based on cobalt and chromium, especially complexes thereof having benzimidazole ligands.

  生产共轭二烯的同聚物或共聚物的过程，包括将至少含有一种共轭二烯的单体材料与催化剂体系接触，所述催化剂体系包括两种或更多不同的过渡金属化合物和可选的一个或多个活化剂。首选的过渡金属化合物基于钴和铬，特别是具有苯并咪唑配体的配合物。