p-2-Aethylbutylanilin | 34895-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-2-Aethylbutylanilin
• 英文别名: 4-(2-Ethylbutyl)aniline；4-(2-ethylbutyl)aniline
• CAS: 34895-13-1
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: YCPBALFJJBLWKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  p-2-Aethylbutylanilin 、 disodium 3-hydroxy-2,7-naphthalenedisulfonate 生成 monosodium mono((E)-4-((4-(2-ethylbutyl)phenyl)diazenyl)-3-hydroxynaphthalene-2,7-disulfonate)
  参考文献：
  名称：

  Datyner,A. et al., Australian Journal of Chemistry, 1971, vol. 24, p. 1845 - 1852

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基溴代丁烷 、 苯胺 生成 p-2-Aethylbutylanilin
  参考文献：
  名称：

  Datyner,A. et al., Australian Journal of Chemistry, 1971, vol. 24, p. 1845 - 1852

  摘要：

  DOI：

文献信息

• [EN] MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF<br/>[FR] LIGANDS MACROCYCLIQUES AYANT DES FRACTIONS CHÉLATANTES PENDANTES ET LEURS COMPLEXES
  申请人：LUMIPHORE INC

  公开号：WO2018045385A1

  公开（公告）日：2018-03-08

  The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

  该发明涉及可用于治疗和诊断应用的化学化合物和配合物。
• Steroids and protein-conjugates thereof
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US10711032B2

  公开（公告）日：2020-07-14

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

  本文描述的蛋白质类固醇共轭物可用于向细胞靶向输送糖皮质激素（GCs）等。
• STEROIDS AND PROTEIN-CONJUGATES THEREOF
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US20180155389A1

  公开（公告）日：2018-06-07

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
• DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS
  申请人：PIERRE FABRE MEDICAMENT

  公开号：US20180222858A1

  公开（公告）日：2018-08-09

  The present invention concerns a compound of following formula (I): where: —R 1 is H or OH, —R 2 is a (C 1 -C 6 )alkyl, COOH, COO—((C 1 -C 6 )alkyl) or thiazolyl group, —R 3 is H or a (C 1 -C 6 )alkyl group, and —R 4 is: ▪a straight-chain or branched, saturated or unsaturated hydrocarbon group having 1 to 8 carbon atoms substituted by one or more groups chosen from among OH and NR 5 R 6 , ▪—(CH 2 CH 2 X 1 )(CH 2 CH 2 X 2 ) a2 (CH 2 CH 2 X 3 ) a3 (CH 2 CH 2 X 4 ) a4 (CH 2 CH 2 X 5 ) a5 R 7 , ▪an aryl-(C 1 -C 8 )alkyl group substituted by one or more groups chosen from among OH and NR 9 R 10 groups, or ▪a heterocycle-(C 1 -C 8 )alkyl group optionally substituted by one or more groups chosen from among (C 1 -C 6 )alkyl, OH and NR 12 R 13 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.