4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene | 935659-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene
• 英文别名: 1-Bromo-2,4-bis(diphenylphosphorylmethyl)benzene
• CAS: 935659-32-8
• 化学式: C₃₂H₂₇BrO₂P₂
• 分子量: 585.417
• InChiKey: ZGTBNSYLRURZBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene 在 奎宁环 、 tris-(dibenzylideneacetone)dipalladium(0) 三氯化锇 、 potassium carbonate 、 三苯基膦 、 potassium hexacyanoferrate(III) 作用下， 以 水 、 甲苯 、 叔丁醇 为溶剂， 反应 24.0h， 生成 1-[2,4-Bis(diphenylphosphorylmethyl)phenyl]ethane-1,2-diol
  参考文献：
  名称：

  Expedient Synthesis of Substituted (Diphenylphosphinoylmethyl)benzenes

  摘要：

  GraphicAn efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported

  DOI：

  10.1021/jo062114k
• 作为产物：
  描述：

  4-溴-1,3-苯二甲酸 、 二苯基氯化膦 在 水 作用下， 反应 2.0h， 以54%的产率得到4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene
  参考文献：
  名称：

  Expedient Synthesis of Substituted (Diphenylphosphinoylmethyl)benzenes

  摘要：

  GraphicAn efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported

  DOI：

  10.1021/jo062114k

文献信息

• Expedient Synthesis of Substituted (Diphenylphosphinoylmethyl)benzenes
  作者：Sean P. Bew、Rebecca A. Brimage、David L. Hughes、Laurent Legentil、Sunil V. Sharma、Martin A. Wilson

  DOI：10.1021/jo062114k

  日期：2007.3.1

  GraphicAn efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported