1-(4,7-dimethyl-2-tosylisoindolin-5-yl)ethanol | 1453297-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4,7-dimethyl-2-tosylisoindolin-5-yl)ethanol
• 英文别名: 1-[4,7-Dimethyl-2-(4-methylphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]ethanol；1-[4,7-dimethyl-2-(4-methylphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]ethanol
• CAS: 1453297-33-0
• 化学式: C₁₉H₂₃NO₃S
• 分子量: 345.463
• InChiKey: ZUMMZDNOIVPEHK-UHFFFAOYSA-N

物化性质

• 沸点：
  524.3±60.0 °C(predicted)
• 密度：
  1.248±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-丁炔-2-醇 、 N,N-bis(2-butynyl)-(4-methylphenyl)sulfonamide 在 [{Ir(H)[rac-binap]}2(μ-I)3]I 作用下， 以 neat (no solvent) 为溶剂， 以62%的产率得到1-(4,7-dimethyl-2-tosylisoindolin-5-yl)ethanol
  参考文献：
  名称：

  Solvent-Free Iridium(III)-Catalyzed [2+2+2] Cycloaddition Providing Access to Fused Arenes: Isoindolines, Dihydroisobenzofurans and Indanes

  摘要：

  A practical and convenient solvent-free iridium-catalyzed [2+2+2] cycloaddition of alpha,omega-diynes and alkynes to prepare fused arenes has been developed. The method has shown high efficiency as isoindolines, dihydroisobenzofurans and indanes have been synthesized in good to excellent yields.

  DOI：

  10.1055/s-0033-1338483

文献信息

• Solvent-Free Iridium(III)-Catalyzed [2+2+2] Cycloaddition Providing Access to Fused Arenes: Isoindolines, Dihydroisobenzofurans and Indanes
  作者：Véronique Michelet、Virginie Ratovelomanana-Vidal、Anne-Laure Auvinet

  DOI：10.1055/s-0033-1338483

  日期：——

  A practical and convenient solvent-free iridium-catalyzed [2+2+2] cycloaddition of alpha,omega-diynes and alkynes to prepare fused arenes has been developed. The method has shown high efficiency as isoindolines, dihydroisobenzofurans and indanes have been synthesized in good to excellent yields.