2-(4-chlorophenyl)-2-fluoro-1-phenylpropan-1-one | 1355165-42-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(4-chlorophenyl)-2-fluoro-1-phenylpropan-1-one
• CAS: 1355165-42-2
• 化学式: C₁₅H₁₂ClFO
• 分子量: 262.711
• InChiKey: KNXFNINVUQXPSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴氯苯 、 1-(2-氟苯基)-1-丙酮 在 potassium phosphate 、 palladium diacetate 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 8.0h， 以82%的产率得到2-(4-chlorophenyl)-2-fluoro-1-phenylpropan-1-one
  参考文献：
  名称：

  Palladium-catalyzed direct α-arylation of α-fluoroketones: A straightforward route to α-fluoro-α-arylketones

  摘要：

  The palladium-catalyzed direct alpha-arylation of both open-chain and cyclic alpha-fluoroketones by using P(o-tolyl)(3) or RuPhos as ligand and K3PO4 center dot 3H(2)O as mild base has been developed. This method allows a variety of quaternary alpha-aryl-alpha-fluoroketones to be easily prepared. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.08.004

文献信息

• Palladium-catalyzed direct α-arylation of α-fluoroketones: A straightforward route to α-fluoro-α-arylketones
  作者：Chen Guo、Ruo-Wen Wang、Yong Guo、Feng-Ling Qing

  DOI：10.1016/j.jfluchem.2011.08.004

  日期：2012.1

  The palladium-catalyzed direct alpha-arylation of both open-chain and cyclic alpha-fluoroketones by using P(o-tolyl)(3) or RuPhos as ligand and K3PO4 center dot 3H(2)O as mild base has been developed. This method allows a variety of quaternary alpha-aryl-alpha-fluoroketones to be easily prepared. (C) 2011 Elsevier B.V. All rights reserved.